This feature covers the "References" section of the current Evolving Paradigms in Lymphoma issue.
References
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015.CA Cancer J Clin. 2015;65(1):5-29.
National Cancer Institute. SEER Stat Fact Sheets: Hodgkin Lymphoma. Bethesda, Maryland; 2015. http://seer.cancer.gov/statfacts/html/hodg.html. Accessed Au- gust 14, 2015.
Stathis A, Younes A. The new therapeutical scenario of Hodgkin lymphoma.Ann Oncol. 2015;26(10):2026-2033.
Townsend W, Linch D. Hodgkin’s lymphoma in adults.Lancet. 2012;380(9844):836- 847.
National Cancer Institute. SEER Stat Fact Sheets: Non-Hodgkin Lymphoma. Bethes- da, Maryland; 2015. http://seer.cancer.gov/statfacts/html/nhl.html. Accessed July 15, 2015.
Müller AMS, Ihorst G, Mertelsmann R, Engelhardt M. Epidemiology of non-Hodg- kin’s lymphoma (NHL): trends, geographic distribution, and etiology.Ann Hematol. 2005;84(1):1-12.
Ambinder RF. Infectious etiology of lymphoma. In: Non-Hodgkin Lymphomas. 2nd ed. Wolters Kluwer and Lippincott Williams and Wilkins; 2010, pp 83-101.
Swerdlow S, Campo E, Harris N, et al.WHO Classification of Tumours of Haemato- poietic and Lymphoid Tissues. 4th ed. Lyon, France: IARC Press; 2008.
Shankland KR, Armitage JO, Hancock BW. Non-Hodgkin lymphoma.Lancet. 2012;380(9844):848-857.
National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Hodgkin Lymphoma; 2015. www.nccn.org/professionals/physician_gls/ pdf/nhl.pdf. Accessed August 15, 2015.
National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Non-Hodgkin’s Lymphomas; 2015. www.nccn.org/professionals/physi- cian_gls/pdf/nhl.pdf. Accessed August 15, 2015.
Elstrom R, Guan L, Baker G, et al. Utility of FDG-PET scanning in lymphoma by
WHO-classification.Blood. 2003;101(10):3875-3876. 13. Kobe C, Dietlein M, Franklin J, et al. Positron emission tomography has a high negative predictive value for progression or early relapse for patients with residual disease after first-line chemotherapy in advanced-stage Hodgkin lymphoma.Blood. 2008;112(10):3989-3994.
Wu L-M, Chen F-Y, Jiang X-X, Gu H-Y, Yin Y, Xu J-R. 18F-FDG PET, combined FDG- PET/CT and MRI for evaluation of bone marrow infiltration in staging of lympho- ma: a systematic review and meta-analysis.Eur J Radiol. 2012;81(2):303-311.
Buchmann I, Reinhardt M, Elsner K, et al. 2-(fluorine-18)fluoro-2-deoxy-D-glucose positron emission tomography in the detection and staging of malignant lym- phoma. A bicenter trial.Cancer. 2001;91(5):889-899.
Rigacci L, Vitolo U, Nassi L, et al. Positron emission tomography in the staging of patients with Hodgkin’s lymphoma. A prospective multicentric study by the Inter- gruppo Italiano Linfomi.Ann Hematol. 2007;86(12):897-903.
Cerci JJ, Trindade E, Buccheri V, et al. Consistency of FDG-PET accuracy and cost- effectiveness in initial staging of patients with Hodgkin lymphoma across jurisdic- tions.Clin Lymphoma Myeloma Leuk. 2011;11(4):314-320.
Gallamini A, Hutchings M, Rigacci L, et al. Early interim 2-[18F]fluoro-2-deoxy-D- glucose positron emission tomography is prognostically superior to international prognostic score in advanced-stage Hodgkin’s lymphoma: a report from a joint Italian-Danish study.J Clin Oncol. 2007;25(24):3746-3752.
Meignan M, Gallamini A, Meignan M, Gallamini A, Haioun C. Report on the First International Workshop on Interim-PET-Scan in Lymphoma.Leuk Lymphoma. 2009;50(8):1257-1260.
Carbone PP, Kaplan HS, Musshoff K, Smithers DW, Tubiana M. Report of the Com- mittee on Hodgkin’s Disease Staging Classification.Cancer Res. 1971;31(11):1860- 1861.
Lister TA, Crowther D, Sutcliffe SB, et al. Report of a committee convened to discuss the evaluation and staging of patients with Hodgkin’s disease: Cotswolds meeting.J Clin Oncol. 1989;7(11):1630-1636.
Engert A, Plütschow A, Eich HT, et al. Reduced treatment intensity in patients with early-stage Hodgkin’s lymphoma.N Engl J Med. 2010;363(7):640-652.
Hasenclever D, Diehl V. A prognostic score for advanced Hodgkin’s disease. Inter- national Prognostic Factors Project on Advanced Hodgkin’s Disease.N Engl J Med. 1998;339(21):1506-1514.
Canellos GP, Rosenberg SA, Friedberg JW, Lister TA, DeVita VT. Treatment of Hodg- kin lymphoma: A 50-year perspective.J Clin Oncol. 2014;32(3):163-168.
The International Non-Hodgkin’s Lymphoma Prognostic Factors Project. A predictive model for aggressive non-Hodgkin’s lymphoma.N Engl J Med. 1993;329(14):987-994.
Solal-Céligny P, Roy P, Colombat P, et al. Follicular Lymphoma International Prog- nostic Index.Blood. 2004;104(5):1258-1265.
Rosenwald A, Wright G, Chan WC, et al. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma.N Engl J Med. 2002;346(25):1937-1947.
Xing X, Feldman AL. Anaplastic large cell lymphomas: ALK positive, ALK negative, and primary cutaneous.Adv Anat Pathol. 2015;22(1):29-49.
Juweid ME, Wiseman GA, Vose JM, et al. Response assessment of aggressive non-Hodgkin’s lymphoma by integrated International Workshop Criteria and fluorine-18fluorodeoxyglucose positron emission tomography.J Clin Oncol. 2005;23(21):4652-4661.
Barrington SF, Mikhaeel NG, Kostakoglu L, et al. Role of imaging in the staging and response assessment of lymphoma: consensus of the International Conference on Malignant Lymphomas Imaging Working Group.J Clin Oncol. 2014; 32(27):3048- 3058:
von Tresckow B, Plütschow A, Fuchs M, et al. Dose-intensification in early unfavor- able Hodgkin’s lymphoma: final analysis of the German Hodgkin Study Group HD14 trial.J Clin Oncol. 2012;30(9):907-913.
Radford J, Barrington S, Counsell N, et al. Involved field radiotherapy versus no further treatment in patients with clinical stages IA and IIA Hodgkin lymphoma and a “negative” PET scan after 3 cycles ABVD. Results of the UK NCRI RAPID Trial. Presented at: 2012 ASH Annual Meeting; Atlanta, GA; December 8-11, 2012. Abstract 547.
Federico M, Luminari S, Iannitto E, et al. ABVD compared with BEACOPP compared with CEC for the initial treatment of patients with advanced Hodgkin’s lym- phoma: results from the HD2000 Gruppo Italiano per lo Studio dei Linfomi Trial.J Clin Oncol. 2009;27(5):805-811.
Skoetz N, Trelle S, Rancea M, et al. Effect of initial treatment strategy on survival of patients with advanced-stage Hodgkin’s lymphoma: a systematic review and network meta-analysis.Lancet Oncol. 2013;14(10):943-952.
Viviani S, Zinzani PL, Rambaldi A, et al. ABVD versus BEACOPP for Hodgkin’s lymphoma when high-dose salvage is planned.N Engl J Med. 2011;365(3):203-212.
Kuruvilla J, Keating A, Crump M. How I treat relapsed and refractory Hodgkin lymphoma.Blood. 2011;117(16):4208-4217.
Stein H, Mason DY, Gerdes J, et al. The expression of the Hodgkin’s disease associ- ated antigen Ki-1 in reactive and neoplastic lymphoid tissue: evidence that Reed- Sternberg cells and histiocytic malignancies are derived from activated lymphoid cells.Blood. 1985;66(4):848-858.
Francisco JA, Cerveny CG, Meyer DL, et al. cAC10-vcMMAE, an anti-CD30mono- methyl auristatin E conjugate with potent and selective antitumor activity.Blood. 2003;102(4):1458-1465.
Younes A, Bartlett NL, Leonard JP, et al. Brentuximab vedotin (SGN-35) for relapsed CD30-positive lymphomas.N Engl J Med. 2010;363(19):1812-1821.
Younes A, Gopal AK, Smith SE, et al. Results of a pivotal phase II study of brentux- imab vedotin for patients with relapsed or refractory Hodgkin’s lymphoma.J Clin Oncol. 2012;30(18):2183-2189.
Moskowitz CH, Nademanee A, Masszi T, et al. Brentuximab vedotin as consolida- tion therapy after autologous stem-cell transplantation in patients with Hodgkin’s lymphoma at risk of relapse or progression (AETHERA): a randomised, double- blind, placebo-controlled, phase 3 trial.Lancet. 2015;385(9980):1853-1862.
US Food and Drug Administration. Brentuximab Vedotin Approval. August 2015. http://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm458815. htm. Accessed August 19, 2015.
Weber J. Immune checkpoint proteins: a new therapeutic paradigm for cancerpre- clinical background: CTLA-4 and PD-1 blockade.Semin Oncol. 2010;37(5):430-439.
Ansell SM, Lesokhin AM, Borrello I, et al. PD-1 blockade with nivolumab in re- lapsed or refractory Hodgkin’s lymphoma.N Engl J Med. 2015;372(4):311-319.
Coiffier B, Lepage E, Brière J, et al. CHOP Chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma.N Engl J Med. 2002;346(4):235-242.
Habermann TM, Weller EA, Morrison VA, et al. Rituximab-CHOP versus CHOP alone or with maintenance rituximab in older patients with diffuse large B-cell lymphoma.J Clin Oncol. 2006;24(19):3121-3127.
Greb A, Bohlius J, Schiefer D, Schwarzer G, Schulz H, Engert A. High-dose che- motherapy with autologous stem cell transplantation in the first line treatment of aggressive non-Hodgkin lymphoma (NHL) in adults.Cochrane Database Syst Rev. 2008;(1):CD004024.
Pfreundschuh M, Schubert J, Ziepert M, et al. Six versus eight cycles of bi-weekly CHOP-14 with or without rituximab in elderly patients with aggressive CD20+ B-cell lymphomas: a randomised controlled trial (RICOVER-60).Lancet Oncol. 2008;9(2):105-116.
Nowakowski GS, LaPlant B, Macon WR, et al. Lenalidomide combined with R-CHOP overcomes negative prognostic impact of non-germinal center B-cell phenotype in newly diagnosed diffuse large B-cell lymphoma: a phase II study.J Clin Oncol. 2015;33(3):251-257.
Younes A, Thieblemont C, Morschhauser F, et al. Combination of ibrutinib with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) for treatment-naive patients with CD20-positive B-cell non-Hodgkin lymphoma: a non-randomised, phase 1b study.Lancet Oncol. 2014;15(9):1019-1026.
Hagberg H, Gisselbrecht C, CORAL study group. Randomised phase III study of R- ICE versus R-DHAP in relapsed patients with CD20 diffuse large B-cell lymphoma (DLBCL) followed by high-dose therapy and a second randomisation to mainte- nance treatment with rituximab or not: an update of the CORAL study.Ann Oncol. 2006;17(suppl 4):iv31-iv32.
Gisselbrecht C, Schmitz N, Mounier N, et al. Rituximab maintenance therapy after autologous stem-cell transplantation in patients with relapsed CD20(+) diffuse large B-cell lymphoma: final analysis of the collaborative trial in relapsed aggressive lymphoma.J Clin Oncol. 2012;30(36):4462-4469.
van Kampen RJW, Canals C, Schouten HC, et al. Allogeneic stem-cell transplantation as salvage therapy for patients with diffuse large B-cell non-Hodgkin’s lymphoma relapsing after an autologous stem-cell transplantation: an analysis of the European Group for Blood and Marrow Transplantation Registry.J Clin Oncol. 2011;29(10):1342-1348.
Guadagnolo BA, Li S, Neuberg D, et al. Long-term outcome and mortality trends in early-stage, grade 1-2 follicular lymphoma treated with radiation therapy.Int J Radiat Oncol Biol Phys. 2006;64(3):928-934.
Link BK, Maurer MJ, Nowakowski GS, et al. Rates and outcomes of follicular lym- phoma transformation in the immunochemotherapy era: a report from the Univer- sity of Iowa/MayoClinic Specialized Program of Research Excellence Molecular Epidemiology Resource.J Clin Oncol. 2013;31(26):3272-3278.
Solal-Céligny P, Bellei M, Marcheselli L, et al. Watchful waiting in low-tumor bur- den follicular lymphoma in the rituximab era: results of an F2-study database.J Clin Oncol. 2012;30(31):3848-3853.
Ardeshna KM, Qian W, Smith P, et al. Rituximab versus a watch-and-wait approach in patients with advanced-stage, asymptomatic, non-bulky follicular lymphoma: an open-label randomised phase 3 trial.Lancet Oncol. 2014;15(4):424-435.
Kahl BS, Hong F, Williams ME, et al. Rituximab extended schedule or re-treatment trial for low-tumor burden follicular lymphoma: eastern cooperative oncology group protocol e4402.J Clin Oncol. 2014;32(28):3096-3102.
Flinn IW, van der Jagt R, Kahl BS, et al. Randomized trial of bendamustine- rituximab or R-CHOP/R-CVP in first-line treatment of indolent NHL or MCL: the BRIGHT study.Blood. 2014;123(19):2944-2952.
Salles G, Seymour JF, Offner F, et al. Rituximab maintenance for 2 years in pa- tients with high tumour burden follicular lymphoma responding to rituximab plus chemotherapy (PRIMA): a phase 3, randomised controlled trial.Lancet. 2011;377(9759):42-51.
Morschhauser F, Radford J, Van Hoof A, et al. Phase III trial of consolidation therapy with yttrium-90-ibritumomab tiuxetan compared with no additional therapy after first remission in advanced follicular lymphoma.J Clin Oncol. 2008;26(32):5156-5164.
Schouten HC, Qian W, Kvaloy S, et al. High-dose therapy improves progression-free survival and survival in relapsed follicular non-Hodgkin’s lymphoma: results from the randomized European CUP trial.J Clin Oncol. 2003;21(21):3918-3927.
Evens AM, Vanderplas A, LaCasce AS, et al. Stem cell transplantation for follicular lymphoma relapsed/refractory after prior rituximab: a comprehensive analysis from the NCCN lymphoma outcomes project.Cancer. 2013;119(20):3662-3671.
Romaguera JE, Medeiros LJ, Hagemeister FB, et al. Frequency of gastrointesti- nal involvement and its clinical significance in mantle cell lymphoma.Cancer. 2003;97(3):586-591.
Martin P, Chadburn A, Christos P, et al. Outcome of deferred initial therapy in mantle-cell lymphoma.J Clin Oncol. 2009;27(8):1209-1213.
Rummel MJ, Niederle N, Maschmeyer G, et al. Bendamustine plus rituximab versus CHOP plus rituximab as first-line treatment for patients with indolent and mantle-cell lymphomas: an open-label, multicentre, randomised, phase 3 non- inferiority trial.Lancet. 2013;381(9873):1203-1210.
Romaguera JE, Fayad LE, Feng L, et al. Ten-year follow-up after intense chemoimmu- notherapy with rituximab-hyperCVAD alternating with rituximab-high dose metho- trexate/cytarabine (R-MA) and without stem cell transplantation in patients with untreated aggressive mantle cell lymphoma.Br J Haematol. 2010;150(2):200-208.
Dreyling M, Lenz G, Hoster E, et al. Early consolidation by myeloablative radio- chemotherapy followed by autologous stem cell transplantation in first remis- sion significantly prolongs progression-free survival in mantle-cell lymphoma: results of a prospective randomized trial of the European MCL Network.Blood. 2005;105(7):2677-2684.
Ansell SM. Non-Hodgkin lymphoma: diagnosis and treatment.Mayo Clin Proc. 2015;90(8):1152-1163.
Savage KJ, Harris NL, Vose JM, et al. ALK-anaplastic large-cell lymphoma is clini- cally and immunophenotypically different from both ALK+ ALCL and peripheral T-cell lymphoma, not otherwise specified: report from the International Peripheral T-Cell Lymphoma Project.Blood. 2008;111(12):5496-5504.
Zhang X-M, Li Y-X, Wang W-H, et al. Favorable outcome with doxorubicin-based chemotherapy and radiotherapy for adult patients with early stage primary systemic anaplastic large-cell lymphoma.Eur J Haematol. 2013;90(3):195-201.
Hapgood G, Savage KJ. The biology and management of systemic anaplastic large cell lymphoma.Blood. 2015;126(1):17-25.
Ellin F, Landström J, Jerkeman M, Relander T. Real-world data on prognostic factors and treatment in peripheral T-cell lymphomas: a study from the Swedish Lym- phoma Registry.Blood. 2014;124(10):1570-1577.
Schmitz N, Trümper L, Ziepert M, et al. Treatment and prognosis of mature T-cell and NK-cell lymphoma: an analysis of patients with T-cell lymphoma treated in studies of the German High-Grade Non-Hodgkin Lymphoma Study Group.Blood. 2010;116(18):3418-3425.
Eyre TA, Khan D, Hall GW, Collins GP. Anaplastic lymphoma kinase-positive ana- plastic large cell lymphoma: current and future perspectives in adult and paediat- ric disease.Eur J Haematol. 2014;93(6):455-468.
Smith SM, Burns LJ, van Besien K, et al. Hematopoietic cell transplantation for sys- temic mature T-cell non-Hodgkin lymphoma.J Clin Oncol. 2013;31(25):3100-3109.
Hallek M. Chronic lymphocytic leukemia: 2015 Update on diagnosis, risk stratifi- cation, and treatment.Am J Hematol. 2015;90(5):446-460.
Cramer P, Hallek M. Prognostic factors in chronic lymphocytic leukemiawhat do we need to know?Nat Rev Clin Oncol. 2011;8(1):38-47.
CLL Trialists’ Collaborative Group. Chemotherapeutic options in chronic lym- phocytic leukemia: a meta-analysis of the randomized trials.J Natl Cancer Inst. 1999;91(10):861-868.
Burger JA, Keating MJ, Wierda WG, et al. Safety and activity of ibrutinib plus ritux- imab for patients with high-risk chronic lymphocytic leukaemia: a single-arm, phase 2 study.Lancet Oncol. 2014;15(10):1090-1099.
Byrd JC, Furman RR, Coutre SE, et al. Targeting BTK with ibrutinib in relapsed chronic lymphocytic leukemia.N Engl J Med. 2013;369(1):32-42.
Dreger P, Schetelig J, Andersen N, et al. Managing high-risk CLL during transi- tion to a new treatment era: stem cell transplantation or novel agents?Blood. 2014;124(26):3841-3849.
Forero-Torres A, Leonard JP, Younes A, et al. A phase II study of SGN-30 (anti-CD30 mAb) in Hodgkin lymphoma or systemic anaplastic large cell lymphoma.Br J Haematol. 2009;146(2):171-179.
Pro B, Advani R, Brice P, et al. Brentuximab vedotin (SGN-35) in patients with relapsed or refractory systemic anaplastic large-cell lymphoma: results of a phase II study.J Clin Oncol. 2012;30(18):2190-2196.
Pro B, Advani R, Brice P, et al. Three-year survival results from an ongoing phase 2 study of brentuximab vedotin in patients with relapsed or refractory systemic ana- plastic large cell lymphoma. December 2013. https://ash.confex.com/ash/2013/ webprogram/Paper57591.html. Accessed August 19, 2015.
Goede V, Fischer K, Busch R, et al. Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions.N Engl J Med. 2014;370(12):1101-1110.
Lannutti BJ, Meadows SA, Herman SEM, et al. CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability.Blood. 2011;117(2):591-594.
Brown JR, Byrd JC, Coutre SE, et al. Idelalisib, an inhibitor of phosphatidylinositol 3-kinase p110δ, for relapsed/refractory chronic lymphocytic leukemia.Blood. 2014;123(22):3390-3397.
Flinn IW, Kahl BS, Leonard JP, et al. Idelalisib, a selective inhibitor of phosphati- dylinositol 3-kinase-δ, as therapy for previously treated indolent non-Hodgkin lymphoma.Blood. 2014;123(22):3406-3413.
Gopal AK, Kahl BS, de Vos S, et al. PI3Kδ inhibition by idelalisib in patients with relapsed indolent lymphoma.N Engl J Med. 2014;370(11):1008-1018.
Kahl BS, Spurgeon SE, Furman RR, et al. A phase 1 study of the PI3Kδ inhibitor idelalisib in patients with relapsed/refractory mantle cell lymphoma (MCL).Blood. 2014;123(22):3398-3405.
Kane RC, Dagher R, Farrell A, et al. Bortezomib for the treatment of mantle cell lymphoma.Clin Cancer Res. 2007;13(18):5291-5294.
Cavalli F, Rooney B, Pei L, Van De Velde H, Robak T. Randomized phase 3 study of rituximab, cyclophosphamide, doxorubicin, and prednisone plus vincristine (R- CHOP) or bortezomib (VR-CAP) in newly diagnosed mantle cell lymphoma (MCL) patients (pts) ineligible for bone marrow transplantation (BMT).J Clin Oncol. 2014: Abstract 8500.
Chamberlain PP, Lopez-Girona A, Miller K, et al. Structure of the human Cereblon- DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs.Nat Struct Mol Biol. 2014;21(9):803-809.
Habermann TM, Lossos IS, Justice G, et al. Lenalidomide oral monotherapy produces a high response rate in patients with relapsed or refractory mantle cell lymphoma.Br J Haematol. 2009;145(3):344-349.
Witzig TE, Vose JM, Zinzani PL, et al. An international phase II trial of single-agent lenalidomide for relapsed or refractory aggressive B-cell non-Hodgkin’s lymphoma.Ann Oncol. 2011;22(7):1622-1627.
Goy A, Sinha R, Williams ME, et al. Single-agent lenalidomide in patients with mantle-cell lymphoma who relapsed or progressed after or were refractory to bortezomib: phase II MCL-001 (EMERGE) study.J Clin Oncol. 2013;31(29):3688-3695.
Katz B-Z, Herishanu Y. Therapeutic targeting of CD19 in hematological malignancies: past, present, future and beyond.Leuk Lymphoma. 2014;55(5):999-1006.
Hijazi Y, Klinger M, Schub A, et al. Blinatumomab exposure and pharmacodynamic response in patients with non-Hodgkin lymphoma (NHL).J Clin Oncol. 2013. http://meetinglibrary.asco.org/content/110626-132. Accessed August 13, 2015.
ClinicalTrials.gov. Clinical study with blinatumomab in patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL). https://clinicaltrials.gov/ct2/show/NCT01741792. Accessed August 13, 2015.
ClinicalTrials.gov. A study of GDC-0199 (ABT-199) plus MabThera/Rituxan (rituximab) compared with bendamustine plus MabThera/Rituxan (Rituximab) in patients with relapsed or refractory chronic lymphocytic leukemia. https://clini- caltrials.gov/ct2/show/NCT02005471. Accessed August 13, 2015.
ClinicalTrials.gov. A study evaluating the safety and pharmacokinetics of ABT-199 in combination with bendamustine/rituximab (BR) in subjects with relapsed or refractory non-Hodgkin’s lymphoma. https://clinicaltrials.gov/ct2/show/ NCT01594229. Accessed August 20, 2015.
ClinicalTrials.gov. A study evaluating the safety and efficacy of GDC-0199 (ABT- 199) plus bendamustine + rituximab (BR) in comparison with BR or GDC-0199 plus rituximab in patients with relapsed and refractory follicular non-Hodgkin’s lymphoma. https://clinicaltrials.gov/ct2/show/NCT02187861. Accessed August 20, 2015.
ClinicalTrials.gov. Optimal dose finding study ABT-199 and ibrutinib in MCL. https://clinicaltrials.gov/ct2/show/NCT02419560. Accessed August 20, 2015.
ClinicalTrials.gov. Carfilzomib plus belinostat in relapsed/refractory NHL. https:// clinicaltrials.gov/ct2/show/NCT02142530. Accessed August 20, 2015.
ClinicalTrials.gov. EPOCH-R chemotherapy plus bortezomib to treat mantle cell lymphoma. https://clinicaltrials.gov/ct2/show/NCT00114738. Accessed August 16, 2015.
ClinicalTrials.gov. A randomised evaluation of molecular guided therapy for dif- fuse large B-cell lymphoma with bortezomib. https://clinicaltrials.gov/ct2/show/ NCT01324596. Accessed August 20, 2015.
ClinicalTrials.gov. Brentuximab vedotin and bendamustine for the treatment of Hodgkin lymphoma and anaplastic large cell lymphoma (ALCL). https://clinicaltri- als.gov/ct2/show/NCT01657331. Accessed August 20, 2015.
ClinicalTrials.gov. Brentuximab vedotin and lenalidomide for relapsed or refractory diffuse large B-cell Lymphoma. https://clinicaltrials.gov/ct2/show/NCT02086604. Accessed August 20, 2015.
ClinicalTrials.gov. A phase II study of carfilzomib in the treatment of relapsed/re- fractory mantle cell lymphoma. https://clinicaltrials.gov/ct2/show/NCT02042950. Accessed August 20, 2015.
ClinicalTrials.gov. carfilzomib, rituximab, ifosfamide, carboplatin, and etoposide in treating patients with relapsed or refractory diffuse large B-cell lymphoma. https://clinicaltrials.gov/ct2/show/NCT01959698. Accessed August 20, 2015.
ClinicalTrials.gov. A study of treatment ALK(+) systemic anaplastic large cell lymphoma with crizotinib. https://clinicaltrials.gov/ct2/show/NCT02487316. Accessed August 20, 2015.
ClinicalTrials.gov. Study of duvelisib in combination with rituximab vs rituximab in subjects with previously treated follicular lymphoma (DYNAMO + R). https:// clinicaltrials.gov/ct2/show/NCT02204982. Accessed August 13, 2015.
ClinicalTrials.gov. A phase 3 study of duvelisib versus ofatumumab in patients with relapsed or refractory CLL/SLL (DUO). https://clinicaltrials.gov/ct2/show/NCT02004522. Accessed August 13, 2015.
ClinicalTrials.gov. A phase 2 of entospletinib in subjects with relapsed or refrac- tory hematologic malignancies. https://clinicaltrials.gov/ct2/show/NCT01799889. Accessed August 20, 2015.
ClinicalTrials.gov. Everolimus in combination with DHAP in patients with re- lapsed or refractory Hodgkin lymphoma. https://clinicaltrials.gov/ct2/show/ NCT01453504. Accessed August 20, 2015.
ClinicalTrials.gov. Ibrutinib and combination chemotherapy in treating patients with relapsed or refractory diffuse large B-cell lymphoma. https://clinicaltrials. gov/ct2/show/NCT02219737. Accessed August 20, 2015.
ClinicalTrials.gov. Combination of ibrutinib and bortezomib to treat patients with mantle cell lymphoma. https://clinicaltrials.gov/ct2/show/NCT02356458. Ac- cessed August 20, 2015.
ClinicalTrials.gov. Idelalisib in combination with rituximab for previously untreat- ed follicular lymphoma and small lymphocytic lymphoma. https://clinicaltrials. gov/ct2/show/NCT02258529. Accessed August 20, 2015.
ClinicalTrials.gov. Treatment of patients with diffuse large B cell lymphoma who are not suitable for anthracycline containing chemotherapy (INCA). https://clini- caltrials.gov/ct2/show/NCT01679119. Accessed August 13, 2015.
ClinicalTrials.gov. Clinical trial to determinate dose, security and efficacy of lenalidomide and rituximab (LR)-ESHAP in patients with diffuse large B-cell lym- phoma. https://clinicaltrials.gov/ct2/show/NCT02340936. Accessed August 20, 2015.
ClinicalTrials.gov. Lenalidomide plus rituximab followed by lenalidomide versus rituximab maintenance for relapsed/refractory follicular, marginal zone or mantle cell lymphoma. https://clinicaltrials.gov/ct2/show/NCT01996865. Accessed Au- gust 20, 2015.
ClinicalTrials.gov. Study of nivolumab in subjects with Hodgkin’s lymphoma (Reg- istrational) (CheckMate 205). https://clinicaltrials.gov/ct2/show/NCT02181738. Accessed August 13, 2015.
ClinicalTrials.gov. Study of nivolumab in patients with relapsed or refractory dif- fuse large B-cell lymphoma (DLBCL) that have either failed or are not eligible for autologous stem cell transplant (CheckMate 139). https://clinicaltrials.gov/ct2/ show/NCT02038933. Accessed August 13, 2015.
ClinicalTrials.gov. Study of nivolumab in subjects with relapsed or refractory follicular lymphoma (FL) (CheckMate 140). https://clinicaltrials.gov/ct2/show/ NCT02038946. Accessed August 13, 2015.
ClinicalTrials.gov. Obinutuzumab and ICE chemotherapy in refractory/recurrent CD20+ mature NHL. https://clinicaltrials.gov/ct2/show/NCT02393157. Accessed August 20, 2015.
ClinicalTrials.gov. Study of obinutuzumab + chlorambucil, ACP-196 + obinutuzum- ab, and ACP-196 in subjects with previously untreated CLL. https://clinicaltrials. gov/ct2/show/NCT02475681. Accessed August 20, 2015.
ClinicalTrials.gov. Ofatumumab and bendamustine combination therapy compared with bendamustine monotherapy in indolent B-cell non-Hodgkin’s lymphoma (NHL) unresponsive to rituximab or a rituximab-containing regimen. https://clini- caltrials.gov/ct2/show/NCT01077518. Accessed August 20, 2015.
ClinicalTrials.gov. Ofatumumab with or without bendamustine for patients with mantle cell lymphoma ineligible for autologous stem cell transplant. https://clini- caltrials.gov/ct2/show/NCT01437709. Accessed August 13, 2015.
ClinicalTrials.gov. Rapid infusion of ofatumumab in patients with previously treated chronic lymphocytic leukemia. https://clinicaltrials.gov/ct2/show/ NCT01848145. Accessed August 20, 2015.
ClinicalTrials.gov. Panobinostat plus ifosfamide, carboplatin, and etoposide (ICE) compared with ICE for relapsed Hodgkin lymphoma. https://clinicaltrials.gov/ct2/ show/NCT01169636. Accessed August 20, 2015.
ClinicalTrials.gov. Pembrolizumab after ASCT for Hodgkin lymphoma and DLBCL. https://clinicaltrials.gov/ct2/show/NCT02362997. Accessed August 13, 2015.
ClinicalTrials.gov. A study of polatuzumab vedotin (DCDS4501A) in combination with rituximab or obinutuzumab plus bendamustine in patients with relapsed or refractory follicular or diffuse large B-cell lymphoma. https://clinicaltrials.gov/ ct2/show/NCT02257567. Accessed August 20, 2015.
ClinicalTrials.gov. STORM: Temsirolimus, rituximab and DHAP for relapsed and refractory diffuse large B-cell lymphoma. https://clinicaltrials.gov/ct2/show/NCT01653067. Accessed August 20, 2015.
ClinicalTrials.gov. Temsirolimus for relapsed/refractory Hodgkin’s lymphoma. https://clinicaltrials.gov/ct2/show/NCT00838955. Accessed August 20, 2015.
ClinicalTrials.gov. Temsirolimus, bendamustine and rituximab for relapsed follicular lymphoma or mantle cell lymphoma. https://clinicaltrials.gov/ct2/show/NCT01078142. Accessed August 20, 2015.
Younes A, Oki Y, McLaughlin P, et al. Phase 2 study of rituximab plus ABVD in patients with newly diagnosed classical Hodgkin lymphoma.Blood. 2012;119(18):4123-4128.
Fowler NH, Davis RE, Rawal S, et al. Safety and activity of lenalidomide and rituximab in untreated indolent lymphoma: an open-label, phase 2 trial.Lancet Oncol. 2014;15(12):1311-1318.
Borchmann P, Haverkamp H, Lohri A. Addition of rituximab to BEACOPP escalated to improve the outcome of early interim PET positive advanced stage Hodgkin lymphoma patients: Second planned interim analysis of the HD18 study. In: Vol ; 2014. https://ash.confex.com/ash/2014/webprogram/Paper74038.html.
ClinicalTrials.gov. Study of rituximab and brentuximab vedotin for relapsed clas- sical Hodgkin lymphoma. https://clinicaltrials.gov/ct2/show/NCT01900496. Accessed August 13, 2015.
Wierda WG, Padmanabhan S, Chan GW, et al. Ofatumumab is active in patients with fludarabine-refractory CLL irrespective of prior rituximab: results from the phase 2 international study.Blood. 2011;118(19):5126-5129.
Barth MJ, Mavis C, Czuczman MS, Hernandez-Ilizaliturri FJ. Ofatumumab exhibits enhanced in vitro and in vivo activity compared to rituximab in preclinical models of mantle cell lymphoma [published online ahead of print May 11, 2015].Clin Cancer Res. PMID: 25964296.
Furtado M, Dyer MJS, Johnson R, Berrow M, Rule S. Ofatumumab monotherapy in relapsed/refractory mantle cell lymphomaa phase II trial.Br J Haematol. 2014;165(4):575-578.
ClinicalTrials.gov. Ofatumumab in combination with cyclophosphamide, doxo- rubicin hydrochloride, vincristine sulfate, and dexamethasone alternating with ofatumumab in combination with cytarabine and methotrexate in treating patients with newly diagnosed mantle cell lymphoma. https://clinicaltrials.gov/ct2/show/ NCT01527149. Accessed August 13, 2015.
ClinicalTrials.gov. Ofatumumab versus rituximab salvage chemoimmunotherapy followed by autologous stem cell transplant in relapsed or refractory diffuse large B cell lymphoma (ORCHARRD). https://clinicaltrials.gov/ct2/show/NCT01014208. Accessed August 13, 2015.
Micallef INM, Maurer MJ, Wiseman GA, et al. Epratuzumab with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy in patients with previously untreated diffuse large B-cell lymphoma.Blood. 2011;118(15):4053-4061.
Grant BW, Jung S-H, Johnson JL, et al. A phase II trial of extended induction epratu- zumab and rituximab for previously untreated follicular lymphoma: CALGB 50701.Cancer. 2013;119(21).
ClinicalTrials.gov. Study of veltuzumab and 90Y-epratuzumab in relapsed/refrac- tory, aggressive NHL. https://clinicaltrials.gov/ct2/show/NCT01101581. Accessed August 15, 2015.
ClinicalTrials.gov. A randomized, open-label, phase 3 trial of A+AVD versus ABVD as frontline therapy in patients with advanced classical Hodgkin lymphoma. https://clinicaltrials.gov/ct2/show/NCT01712490. Accessed August 13, 2015.
ClinicalTrials.gov. A randomized, double-blind, placebo-controlled, phase 3 study of brentuximab vedotin and CHP (A+CHP) versus CHOP in the frontline treatment of patients with CD30-positive mature T-cell lymphomas. https://clinicaltrials.gov/ ct2/show/NCT01777152. Accessed August 13, 2015.
Chen RW, Palmer J, Martin P, et al. Results of a phase II trial of brentuximab ve- dotin as first line salvage therapy in relapsed/refractory HL prior to AHCT.Blood. 2014;124(21):501-501.
154. Moskowitz AJ, Schöder H, Yahalom J, et al. PET-adapted sequential salvage therapy with brentuximab vedotin followed by augmented ifosamide, carboplatin, and etoposide for patients with relapsed and refractory Hodgkin’s lymphoma: a non-randomised, open-label, single-centre, phase 2 study.Lancet Oncol. 2015;16(3):284-292.
LaCasce A, Bociek R, Matous J, et al. Brentuximab vedotin in combination with bendamustine for patients with Hodgkin lymphoma who are relapsed or refractory after frontline therapy. December 2014. https://ash.confex.com/ash/2014/webpro- gram/Paper67044.html. Accessed August 18, 2015.
ClinicalTrials.gov. A phase 3 trial of brentuximab vedotin(SGN-35) versus physi- cian’s choice (methotrexate or bexarotene) in patients with CD30-positive cutane- ous T-cell lymphoma. https://clinicaltrials.gov/ct2/show/study/NCT01578499. Accessed August 13, 2015.
ClinicalTrials.gov. Brentuximab vedotin and combination chemotherapy in treating younger patients with newly diagnosed hodgkin lymphoma. https://clinicaltrials. gov/ct2/show/NCT02166463. Accessed August 13, 2015.
Mehta A, Forero-Torres A. Development and integration of antibody-drug conjugate in non-Hodgkin lymphoma.Curr Oncol Rep. 2015;17(9):466.
Advani A, Coiffier B, Czuczman MS, et al. Safety, pharmacokinetics, and prelimi- nary clinical activity of inotuzumab ozogamicin, a novel immunoconjugate for the treatment of B-cell non-Hodgkin’s lymphoma: results of a phase I study.J Clin Oncol. 2010;28(12):2085-2093.
Fayad L, Offner F, Smith MR, et al. Safety and clinical activity of a combination therapy comprising two antibody-based targeting agents for the treatment of non- Hodgkin lymphoma: results of a phase I/II study evaluating the immunoconjugate inotuzumab ozogamicin with rituximab.J Clin Oncol. 2013;31(5):573-583.
Wagner-Johnston ND, Goy A, Rodriguez MA, et al. A phase 2 study of inotuzumab ozogamicin and rituximab, followed by autologous stem cell transplant in patients with relapsed/refractory diffuse large B-cell lymphoma.Leuk Lymphoma. March 29, 2015:1-7.
ClinicalTrials.gov. Study of inotuzumab ozogamicin + temsirolimus in patients with relapsed or refractory CD22+ B-cell NH Lymphoma (IOSI-LND-001). https:// clinicaltrials.gov/ct2/show/NCT01535989. Accessed August 13, 2015.
ClinicalTrials.gov. A trial of pembrolizumab (MK-3475) in participants with blood cancers (MK-3475-013)(KEYNOTE-013). https://clinicaltrials.gov/ct2/show/ NCT01953692. Accessed August 13, 2015.
Witzig TE, Reeder CB, LaPlant BR, et al. A phase II trial of the oral mTOR inhibitor everolimus in relapsed aggressive lymphoma.Leukemia. 2011;25(2):341-347.
ClinicalTrials.gov. Epigenetic modulation in relapsed/refractory diffuse large B-cell lymphoma (DLBCL). https://clinicaltrials.gov/ct2/show/NCT00978432. Accessed August 13, 2015.
ClinicalTrials.gov. Safety and efficacy of AEB071 and EVEROLIMUS in patients with CD79-mutant or ABC subtype diffuse large B-cell lymphoma (COE- B071X2103). https://clinicaltrials.gov/ct2/show/NCT01854606. Accessed August 13, 2015.
Hess G, Herbrecht R, Romaguera J, et al. Phase III study to evaluate temsirolimus compared with investigator’s choice therapy for the treatment of relapsed or refrac- tory mantle cell lymphoma.J Clin Oncol. 2009;27(23):3822-3829.
ClinicalTrials.gov. Comparison of 2 doses of temsirolimus (Torisel) in patients with mantle cell lymphoma. https://clinicaltrials.gov/ct2/show/NCT01180049. Ac- cessed August 13, 2015.
ClinicalTrials.gov. Efficacy and safety of idelalisib (GS-1101) in combination with rituximab for previously treated indolent non-Hodgkin lymphomas (Yosemite). https://clinicaltrials.gov/ct2/show/NCT01732913. Accessed August 13, 2015.
Flinn I, Oki Y, Patel M, et al. A phase 1 evaluation of duvelisib (IPI-145), a PI3K-δ,γ inhibitor, in patients with relapsed/refractory iNHL.Blood. 2014;124(21):802-802.
Horwitz SM, Porcu P, Flinn I, et al. Duvelisib (IPI-145), a phosphoinositide-3- kinase-δ,γ inhibitor, shows activity in patients with relapsed/refractory T-cell lymphoma.Blood. 2014;124(21):803-803.
Davids M, Seymour J, Gerecitano J, et al. Phase I study of ABT-199 (GDC-0199) in patients with relapsed/refractory (R/R) non-Hodgkin lymphoma (NHL): responses observed in diffuse large B-cell (DLBCL) and follicular lymphoma (FL) at higher cohort doses.Haematologica. 2014;99: Abstract S1348.
ClinicalTrials.gov. A study to compare the efficacy and safety of obinutuzumab + GDC-0199 versus obinutuzumab + chlorambucil in patients with chronic lym- phocytic leukemia. https://clinicaltrials.gov/ct2/show/NCT02242942. Accessed August 13, 2015.