Mustafa Khasraw, MD, discusses a follow-up trial to the VERTU study for patient with methylated or unmethylated MGMT glioblastoma who responded well to temozolomide chemotherapy and radiation.
Mustafa Khasraw, MD, medical oncologist, neuro-oncologist, and deputy director of the Center for Cancer Immunotherapy at the Duke Cancer Institute, discusses a follow-up trial to the VERTU study (NCT02152982) for patient with methylated or unmethylated MGMT (O6-methylguanine-DNA methyltransferase) glioblastoma who responded well to temozolomide (Temodar) chemotherapy and radiation.
For the follow-up trial, after receiving temozolomide and radiation, patients were randomized to veliparib (ABT-888), a PARP (poly (ADP-ribose) polymerase) inhibitor, with temozolomide and radiation or placebo with temozolomide and radiation. This study has a larger number of patients than the VERTU trial and has been completed, according to Khasraw. He expects the results will come out sometime over the year of 2020. The patients included in this trial were those left out the original VERTU trial.
Khasraw says that moving forward, there needs to be biomarkers and subsets of patients identified for this setting; specifically, those who will benefit from a PARP inhibitor, if there is a benefit at all. He also suggests that other treatments be explored, such as combinations of immunotherapy for patients with glioblastomas.
Phase 3 VERIFY Trial Investigates Rusfertide’s Potential in Polycythemia Vera
July 16th 2024In an interview, Aniket Bankar, MD, discussed the background, design, and goals of the phase 3 VERIFY trial of the hepcidin mimetic rusfertide for the treatment of patients with polycythemia vera.
Read More
Examining Breast Cancer Recurrence Detection Methods in a Community Oncology Setting
July 12th 2024In an interview with Targeted Oncology, Ali Duffens, MD, discussed findings from a study which investigated detecting breast cancer recurrence among women treated at Kaiser Permanente Northern California.
Read More