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Opinion|Videos|March 12, 2025

Insights From JUPITER-02: Plasma EBV Levels and Toripalimab in R/M NPC

Author(s)Nagashree Seetharamu, MD, MBBS

A panelist discusses how low baseline EBV levels still showed benefit from toripalimab in JUPITER-02, though EBV status influences treatment decisions and alternative markers are needed for EBV-negative cases.

Episodes in this series

1 expert is featured in this series.

EP. 1 A 53-Year-Old Woman With Metastatic NPC

1 expert is featured in this series.

EP. 2 Treatment Approaches in Metastatic NPC: First-Line Toripalimab + Gemcitabine/Cisplatin

1 expert is featured in this series.

EP. 3 Insights From JUPITER-02: Plasma EBV Levels and Toripalimab in R/M NPC

1 expert is featured in this series.

EP. 4 Treatment Paradigms in R/M NPC: Evolving Role of Systemic Immunotherapy

1 expert is featured in this series.

EP. 5 Clinical Perspectives for Treatment of R/M NPC

Video content above is prompted by the following:

Please review subgroup analyses from JUPITER-02 for EBV copy number at baseline.
The patient had detectable but low plasma EBV levels (under 2000 IU/ml).
What are your thoughts on overall survival between treatment arms for patients with a baseline plasma EBV copy number of less than 2000 IU/ml?
Please continue to discuss the role of EBV titers and treatment decisions.
How do plasma EBV levels influence your treatment approach?
Do your expectations regarding response to therapy change based on plasma EBV levels?
What if a patient has EBV-negative disease?
Are there other disease response indicators that might be useful in this patient population?

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