Opinion|Videos|March 12, 2025
Treatment Paradigms in R/M NPC: Evolving Role of Systemic Immunotherapy
Author(s)Nagashree Seetharamu, MD, MBBS
A panelist discusses A panelist discusses how the integration of immunotherapy with chemotherapy as first-line treatment for recurrent/metastatic (R/M) nasopharyngeal carcinoma (NPC) is transforming the treatment landscape, with data from trials such as JUPITER-02 and DIPPER demonstrating improved progression-free and overall survival outcomes, while patient selection factors including performance status, comorbidities, PD-L1 expression, and EBV status remain critical considerations for optimizing therapeutic benefit in both the metastatic setting and potentially in neoadjuvant/adjuvant approaches.
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Episodes in this series
Video content above is prompted by the following:
- How can current and emerging immunotherapy regimens impact the treatment landscape for metastatic NPC?
- How can integration of immunotherapy to chemotherapy up front benefit patients with R/M NPC?
- What factors will determine whether patients are suitable for this treatment?
- Please share your thoughts on the DIPPER study and other neoadjuvant/adjuvant regimens.
- What are the clinical implications?
- Please discuss treatment considerations and implications from the use of immunotherapy in NPC.
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