Updated phase 2 data showed a 60% ORR and 86% CNS ORR with frontline silevertinib in non-classical EGFR-mutant NSCLC; FDA discussion supported a phase 3 trial in 2027.
|Videos|October 24, 2013
Reducing Neurotoxicity in Lung Cancer
Author(s)Laurie Gaspar, MD
Laurie Gaspar, MD, discusses reducing neurotoxicity in small cell lung cancer patients.
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Laurie Gaspar, MD, Professor and Chair Department of Radiation Oncology, Grohne Chair in Clinical Oncology, University of Colorado School of Medicine, discusses reducing neurotoxicity in small cell lung cancer patients.
Clinical Pearls
- Neurotoxicity is a phenomenon that occurs with prophylactic cranial radiation or whole brain radiation therapy for brain metastases
- There are several methods of decreasing neurotoxicity, but using medication seems to be the most straightforward approach
- Additional research is being done to focus on reducing or avoiding radiation to the hippocampus, which will help patients keep their memory
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