The Development of a Standardized Ki-67 Assay

Clinical Pearls

Rodrigo Goncalves, MD, postdoctoral fellow, Washington University School of Medicine, discusses the development of a standardized Ki-67 assay.

• Ki-67 assays are cheaper than molecular tests
• Measuring Ki-67 before treatment and 4-6 weeks into treatment can determine whether or not therapy is working
• In this trial, researchers stained slides in a standardized way and used computer software to analyze them
• Ki-67 measurement with the software was reproducible, though researchers were able to measure Ki-67 in the traditional way if needed
• Further trials are needed to verify this information

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