The Toxicity Profile of Concurrent Nivolumab and Ipilimumab

Harriet Kluger, MD, associate professor of medicine, Yale Cancer Center, discusses the toxicity profile of concurrent nivolumab and ipilimumab as seen in a phase I trial.

Clinical Pearls

Harriet Kluger, MD, associate professor of medicine, Yale Cancer Center, discusses the toxicity profile of concurrent nivolumab and ipilimumab as seen in a phase I trial.

  • Additive toxicity was found between these agents.
  • The grade 3/4 adverse event rate was greater than 50%.
  • Most adverse events were reversible with immunosuppressants.

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