Treatment Options for BCR After Local Therapy for Prostate Cancer

Clinical Pearls

Rana R. McKay, MD, a clinical oncology fellow at Dana-Farber Cancer Institute, discusses treatment options for biochemical relapse after definitive local therapy for prostate cancer.

• Biochemical relapse is a heterogenous disease state and is likely related to tumor biology
• Classically, patients who have received a radical prostatectomy may be candidates for salvage radiation therapy with or without hormone therapies
• Patients who initially received primary radiation therapy may be candidates for salvage radical prostatectomy or hormone therapy
• In a previous study, patients in this space were essentially cured following treatment with docetaxel plus estramustine and ADT
• This trial, presented at the 2014 Genitourinary Cancers Symposium, aimed to determine the benefit of docetaxel plus bevacizumab and ADT