Jordyn Sava is an editor for Targeted Oncology.
Lenvatinib/Pembrolizumab/TACE Regimen Improves PFS in Intermediate-Stage HCC
Josep M. Llovet, MD, PhD, discussed the updated data from the LEAP-012 trial in intermediate-stage hepatocellular carcinoma.
Developing a Malignant Hematology and Bone Marrow Transplant APP Fellowship
Janelle Vicens, DNP, APRN, FNP-BC, and Sandra Sepulveda, AGPNP-BC, MSN, BMTCN, discussed what went into developing this Malignant Hematology and Bone Marrow Transplant APP Fellowship.
The Present and Future of Endocrine Therapy in Breast Cancer
In an interview with Targeted Oncology, Erika Hamilton, MD, discussed emerging endocrine therapies that are advancing breast cancer treatment.
FDA Grants Priority Review for TLX101-CDx PET Imaging Agent in Glioma
The FDA accepted the new drug application for TLX101-CDx and granted priority review to the agent in glioma.
Breakthroughs and Challenges in BCL-2 Inhibitor Therapy for CLL Treatment
John Seymour, MD, discusses the development and clinical application of BCL-2 inhibitors for the treatment of CLL.
AI and Deep Learning Revolutionize Radiation Oncology
In an interview with Targeted Oncology, Hina Saeed, MD, discussed how AI and radiomics are changing the landscape of radiation oncology.
FDA Accepts NDA Resubmission of Rivoceranib and Camrelizumab in HCC
The new drug application resubmission of rivoceranib/camrelizumab in the first line in unresectable or metastatic hepatocellular carcinoma is supported by the final survival analysis of CARES-310 trial.
FDA Approves Companion Diagnostic for Vorasidenib in IDH-Mutant Glioma
The FDA has approved the Ion Torrent Oncomine Dx Target Test as a companion diagnostic to identify patients eligible for treatment with vorasidenib.
FREEDOM2 Trial Shows Fedratinib’s Efficacy and Safety in Myelofibrosis
The FREEDOM2 study demonstrates that fedratinib is an effective second-line treatment for myelofibrosis after ruxolitinib failure or intolerance.
Turning Inspiration Into Innovation: Hazim’s Impact on Oncology
Antonious Hazim, MD, shares insights on his journey into oncology, his experiences at the Mayo Clinic, and his ongoing research.
FDA Grants Rare Pediatric Disease Designation to Galinpepimut-S in AML
The FDA granted galinpepimut-S a rare pediatric disease designation for the treatment of pediatric patients with acute myeloid leukemia.
Acclaim-3 Trial Escalates Quaratusugene Ozeplasmid/Atezolizumab Dosing in SCLC
The 0.09 mg/kg dose group of the phase 1 dose-escalation portion of the Acclaim-3 study in extensive-stage small cell lung cancer is completed.
FDA Oks Optune Lua for Use With PD-1/PD-L1 Inhibitors in Metastatic NSCLC
Following promising results from the phase 3 LUNAR trial, the FDA has approved Optune Lua for use with PD-1/PD-L1 inhibitors or docetaxel in patients with metastatic non–small cell lung cancer.
Teclistamab Shows 100% Response Rate in High-Risk Smoldering Myeloma
In an interview with Targeted Oncology, Omar Nadeem, MD, discussed the first results from the Immuno-PRISM study in patients with high-risk smoldering myeloma.
FDA Provides Positive Feedback on AMPLIFY Trial for Prostate Cancer Diagnostic
The phase 3 trial AMPLIFY study plans to test the diagnostic performance of 64Cu-SAR-bisPSMA PET/CT imaging in approximately 220 patients with prostate cancer with biochemical recurrence.
Bringing Bispecific Antibody Therapy to Community Oncology Centers
In an interview with Targeted Oncology, Courtney Van Houzen, PharmD, shared her experience in bringing bispecific antibody treatments to a community setting.
Eric Cheung: Competence and Compassion are Key to Earning Patients' Trust
Eric Cheung, DO, Targeted Oncology’s second 2024 Oncology Icon, discussed his journey in oncology, advances in treatment, and his patient-centered approach to care.
FDA Oks Aquablation vs Prostatectomy Trial in Localized Prostate Cancer
The FDA has approved the WATER IV PCa trial, which will compare the safety and efficacy of Aquablation therapy to radical prostatectomy in patients with localized prostate cancer.
Trial of PT886 and Pembrolizumab Doses First Patient With Gastric/GEJ Cancer
The first patient with advanced gastric and gastroesophageal cancer has been dosed in a trial combining PT886 with pembrolizumab.
Liu’s Insights on Navigating the Fragility of Phase 3 Trials
Yufei Liu, MD, PhD, discussed the importance of careful data interpretation to accurately assess the efficacy of new treatment options in oncology.
Detecting PSMA in Prostate Cancer Noninvasively With Liquid Biopsy
Jacob E. Berchuck, MD, discussed research behind using a blood-based liquid biopsy in prostate cancer and findings presented at the 2024 ESMO Congress.
SunRISe-2 Study of TAR-200 Plus Cetrelimab in MIBC Discontinues
The SunRISe-2 trial evaluating TAR-200 combined with cetrelimab vs chemoradiation in muscle-invasive bladder cancer has been discontinued.
VLS-1488 Gains FDA Fast Track Status in Advanced Ovarian Cancer
The FDA has granted VLS-1488 fast track designation in patients with platinum-resistant high-grade serous ovarian cancer.
Machine Learning-Based Tool Aims to Enhance Stereotactic Radiosurgery Outcomes
In an interview with Targeted Oncology, Rupesh Kotecha, MD, discussed a machine learning tool designed to predict local failure after stereotactic radiosurgery for brain metastases.
Genomic Profiling Offers a Personalized Approach to Breast Cancer Treatment
M. Michele Blackwood, MD, FACS, provided an overview of the significant advancements with personalized medicine with genomic testing in the breast cancer space.
FDA Approves Perioperative Nivolumab in Resectable NSCLC
The FDA has approved nivolumab plus chemotherapy as a neoadjuvant treatment for operable stage IIA to IIIB non–small cell lung cancer, based on data from the phase 3 CheckMate 77T trial.
Assessing Targeted PET Imaging for Advanced Rectal Cancer
In an interview with Targeted Oncology, Jeffrey Wong, MD, discussed the potential and future directions of Cu 64 anti-CEA M5A as a PET imaging agent for advanced rectal cancer.
TMLI Trial Shows Potential in Relapsed/Refractory Leukemia
In an interview, Jeffrey Wong, MD, and Anthony Stein, MD, provided an in-depth discussion on a phase 2 trial of total marrow and lymphoid irradiation with cyclophosphamide and etoposide in high-risk acute leukemia.
Radiopharmaceuticals and Radiation Therapy for Prostate Cancer Treatment
Savita Dandapani, MD, PhD, discussed combining radium-223 and SBRT for metastatic castration-sensitive prostate cancer.
Choosing the Right JAK Inhibitor for Effective Myelofibrosis Treatment
In an interview, Prithviraj Bose, MD, discussed the multiple JAK inhibitors available for the treatment of patients with myeloproliferative neoplasms.