A 67-Year-Old Woman with 3L R/R Large B-cell Lymphoma (LBCL)

An expert discusses the evolving management of relapsed/refractory (R/R) large B-cell lymphoma (LBCL), illustrating how CAR T-cell therapy has transformed third-line treatment from palliative to potentially curative, and emphasizing the importance of timely referral, reassessing eligibility, and individualizing care to optimize patient outcomes.

An expert discusses the multifaceted nature of CAR T-cell therapy for relapsed/refractory (R/R) large B-cell lymphoma (LBCL), emphasizing the need for early multidisciplinary coordination to address clinical, logistical, financial, and psychosocial challenges, ensuring patients are supported throughout the complex treatment journey.

An expert discusses the transformative impact of CAR T-cell therapy in relapsed/refractory large B-cell lymphoma, highlighting long-term data that support durable remission—and potential cure—for a subset of patients, while emphasizing its favorable long-term safety profile and growing role in the evolving standard of care.

An expert discusses the selection of CAR T-cell therapies for third-line large B-cell lymphoma (LBCL), noting that while all approved products show comparable efficacy, differences in co-stimulatory domains, toxicity profiles, manufacturing timelines, and patient-specific factors guide individualized treatment decisions.

An expert discusses the advances in managing CAR T-cell therapy toxicities, emphasizing aggressive early treatment of acute complications, the importance of coordinated long-term monitoring with community providers, and how real-world data validate the therapy’s safety and effectiveness across diverse patient populations.

An expert discusses the emerging role of bispecific antibodies in lymphoma treatment, highlighting their expanding use across treatment lines—including as alternatives or bridges to CAR T-cell therapy—their promising efficacy, more manageable toxicity profiles, and potential to improve patient quality of life through flexible care models.

An expert discusses the evolving landscape of large B-cell lymphoma (LBCL) treatment, highlighting emerging CAR T-cell targets and bispecific antibody strategies, the potential shift toward more personalized, less toxic therapies, and the ongoing challenges of improving patient access, referral, and posttreatment management to maximize outcomes.