A 62-Year-Old Male With Stage III Non-Small Cell Lung Cancer

Video

A 62-Year-Old Male With Stage III Non-Small Cell Lung Cancer

Case: A 62-Year-Old Male With Stage III NSCLC

Initial presentation

  • A 62-year-old man presented with a 2-month history of cough, wheezing, and loss of appetite
  • PMH: Hypertension, medically treated
  • SH: 30 pack-year smoking history; daughter to be married in 11 months, and wants to attend the wedding
  • PE: Right lower lobe wheezing on auscultation

Clinical workup

  • Labs: WNL
  • PFT: FEV1/FVC 60%; DLCO 55%
  • Chest/abdomen/pelvic CT showed a 6.1-cm solid pulmonary lesion in the right lower lobe, right hilar and intrapulmonary lymph node involvement; no evidence of distant metastases
  • PET scan showed large focal hypermetabolic activity in the right lower lobe and small hypermetabolic activity in the surrounding area
  • Contrast‐enhanced MRI of the head showed no brain metastases
  • Bronchoscopic biopsy of the RLL mass and hilar node revealed squamous NSCLC
  • Staging: T3N1M0 — IIIA; ECOG PS 1
    • Unresectable NSCLC based on the extent and location of disease

Treatment

  • Patient was started on cisplatin 50 mg/m2on days 1,8,29 and 36; etoposide 50 mg/m2days 1-5 and 29-33; concurrent RT
  • No disease progression after chemoradiation
  • Durvalumab 10mg/kg IV q2W was started and dose was tolerated well
  • Initial follow-up at 2 months showed partial response, with shrinkage of primary and nodal lesions
Related Videos
Video 3 - "Managing Toxicities and Adverse Reactions in HR+/Her2-Low mBC Therapies"
Video 2 - "EMERALD: Underscoring Key Elacestrant Data + Subgroup Analyses for Informed Therapy Selection"
Video 1 - "A 62-Year-Old Woman with HR+ HER2-low Metastatic Breast Cancer and Lung, Liver, and Bone Metastases and Using Biomarker Testing to Guide Treatment Selection"
John Mascarenhas, MD, an expert on myelofibrosis
John Mascarenhas, MD, an expert on myelofibrosis
John Mascarenhas, MD, an expert on myelofibrosis
John Mascarenhas, MD, an expert on myelofibrosis
Related Content