Advances in the Diagnosis and Treatment of Malignant PEComa

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Experts present clinical cases of PEComa, discuss approaches to treating patients, and share their perspectives on key clinical trial data that may impact treatment decisions.

Introduction to PEComas

EP. 1: Introduction to PEComas

Martee Hensley, MD;Andrew Folpe, MD;Elizabeth Davis, MD;Andrew Wagner, MD, PhD
June 23rd 2023

Andrew Folpe, MD, provides an overview of PEComas, including their incidence rate and malignant tumors.

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Current Treatment Landscape of PEComas

EP. 2: Current Treatment Landscape of PEComas

Martee Hensley, MD;Andrew Folpe, MD;Elizabeth Davis, MD;Andrew Wagner, MD, PhD
June 23rd 2023

Elizabeth Davis, MD, explains the current treatment options available for patients with PEComa.

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Systemic Therapy in Malignant PEComas

EP. 3: Systemic Therapy in Malignant PEComas

Martee Hensley, MD;Andrew Folpe, MD;Elizabeth Davis, MD;Andrew Wagner, MD, PhD
June 30th 2023

Andrew Wagner, MD, PhD, details his typical treatment approach for systemic therapy in patients with malignant PEComa.

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Case 1: Uterine PEComa with a TSC2 Mutation

EP. 4: Case 1: Uterine PEComa with a TSC2 Mutation

Martee Hensley, MD;Andrew Folpe, MD;Elizabeth Davis, MD;Andrew Wagner, MD, PhD
June 30th 2023

Dr Elizabeth Davis presents the case of a young woman with a TSC2-mutated uterine PEComa.

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The AMPECT Trial: Nab-sirolimus in PEComa

EP. 5: The AMPECT Trial: Nab-sirolimus in PEComa

Martee Hensley, MD;Andrew Folpe, MD;Elizabeth Davis, MD;Andrew Wagner, MD, PhD
July 7th 2023

Dr Andrew Wagner shares data from the AMPECT trial investigating the potential role of mTOR inhibitors in PEComa.

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Toxicity Management in Patients Receiving mTOR Inhibitors

EP. 6: Toxicity Management in Patients Receiving mTOR Inhibitors

Martee Hensley, MD;Andrew Folpe, MD;Elizabeth Davis, MD;Andrew Wagner, MD, PhD
July 7th 2023

A discussion on the toxicities associated with mTOR inhibitors and which patients with PEComa would be considered good candidates.

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Treatment Options for PEComas After Progression on Nab-Sirolimus

EP. 7: Treatment Options for PEComas After Progression on Nab-Sirolimus

Martee Hensley, MD;Andrew Folpe, MD;Elizabeth Davis, MD;Andrew Wagner, MD, PhD
July 14th 2023

A review of the available treatment options for a patient with PEComa who have disease progression after nab-sirolimus.

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Case 2: Hormone Receptor Positive Uterine PEComa

EP. 8: Case 2: Hormone Receptor Positive Uterine PEComa

Martee Hensley, MD;Andrew Folpe, MD;Elizabeth Davis, MD;Andrew Wagner, MD, PhD
July 14th 2023

Martee Hensley, MD, presents the case of a post-menopausal woman with a hormone receptor positive malignant uterine PEComa.

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Case 3: Retroperitoneal PEComa

EP. 9: Case 3: Retroperitoneal PEComa

Martee Hensley, MD;Andrew Folpe, MD;Elizabeth Davis, MD;Andrew Wagner, MD, PhD
July 21st 2023

Dr Andrew Wagner presents the case of a young man with a retroperitoneal PEComa.

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The Future of Research in PEComas

EP. 10: The Future of Research in PEComas

Martee Hensley, MD;Andrew Folpe, MD;Elizabeth Davis, MD;Andrew Wagner, MD, PhD
July 21st 2023

The panel shares future areas of research in malignant PEComa that interest them, and how they see the treatment landscape evolving.

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