Advances in the Diagnosis and Treatment of Malignant PEComa

Andrew Folpe, MD, provides an overview of PEComas, including their incidence rate and malignant tumors.

Elizabeth Davis, MD, explains the current treatment options available for patients with PEComa.

Andrew Wagner, MD, PhD, details his typical treatment approach for systemic therapy in patients with malignant PEComa.

Dr Elizabeth Davis presents the case of a young woman with a TSC2-mutated uterine PEComa.

Dr Andrew Wagner shares data from the AMPECT trial investigating the potential role of mTOR inhibitors in PEComa.

A discussion on the toxicities associated with mTOR inhibitors and which patients with PEComa would be considered good candidates.

A review of the available treatment options for a patient with PEComa who have disease progression after nab-sirolimus.

Martee Hensley, MD, presents the case of a post-menopausal woman with a hormone receptor positive malignant uterine PEComa.

Dr Andrew Wagner presents the case of a young man with a retroperitoneal PEComa.

The panel shares future areas of research in malignant PEComa that interest them, and how they see the treatment landscape evolving.