Peter Borchmann, MD, discusses the safety signals seen so far in the phase II JULIET trial investigating tisagenlecleucel, a chimeric antigen receptor T-cell therapy, as a treatment option for patients with diffuse large B-cell lymphoma.
Peter Borchmann, MD, a professor in the department of internal medicine at the University Hospital of Cologne, discusses the safety signals seen so far in the phase II JULIET trial investigating tisagenlecleucel (Kymriah), a chimeric antigen receptor (CAR) T-cell therapy, as a treatment option for patients with diffuse large B-cell lymphoma (DLBCL).
With CAR T-cell therapies, cytokine relapse syndrome (CRS) and neurological events are of special interest in regard to safety. In this study, 58% of patients experienced CRS of some grade, but only 22% of patients experienced grade 3 or greater CRS.
Examining the Non-Hodgkin Lymphoma Treatment Paradigm
July 15th 2022In season 3, episode 6 of Targeted Talks, Yazan Samhouri, MD, discusses the exciting new agents for the treatment of non-Hodgkin lymphoma, the clinical trials that support their use, and hopes for the future of treatment.
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Landgren on MRD as an End Point for Multiple Myeloma Trials
May 1st 2024C. Ola Landgren, MD, PhD, discussed the FDA’s unanimous ODAC vote supporting minimal residual disease as an accelerated approval end point in multiple myeloma and the implications of this vote in the myeloma research field.
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