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Opinion|Videos|June 5, 2025

An Academic Perspective to Making First-Line Treatment Decisions for EGFR-mutated Metastatic NSCLC

Author(s)Rachel E. Sanborn, MD

An expert discusses treatment goals for patients with EGFR-mutated advanced/metastatic NSCLC, how to approach combination therapy with high-risk patients, and how recent data has influenced their practice.

Episodes in this series

EP. 1 A 55-Year-Old Man with EGFR-mutated Advanced/Metastatic NSCLC

EP. 1 A 55-Year-Old Man with EGFR-mutated Advanced/Metastatic NSCLC

EP. 2 Recent Advances in First-Line Combination Therapy for EGFR-mutated Metastatic NSCLC: Exploring Amivantamab + Lazertinib and Osimertinib-Based Regimens

EP. 2 Recent Advances in First-Line Combination Therapy for EGFR-mutated Metastatic NSCLC: Exploring Amivantamab + Lazertinib and Osimertinib-Based Regimens

EP. 3 An Academic Perspective to Making First-Line Treatment Decisions for EGFR-mutated Metastatic NSCLC

EP. 3 An Academic Perspective to Making First-Line Treatment Decisions for EGFR-mutated Metastatic NSCLC

EP. 4 First-Line Treatment Approaches for EGFR-mutated Metastatic NSCLC: Updates from MARIPOSA High-Risk Analyses

EP. 4 First-Line Treatment Approaches for EGFR-mutated Metastatic NSCLC: Updates from MARIPOSA High-Risk Analyses

EP. 5 Management of Adverse Events with First-Line Combination Therapies for EGFR-mutated NSCLC

EP. 5 Management of Adverse Events with First-Line Combination Therapies for EGFR-mutated NSCLC

EP. 6 Considerations for Treatment of Advanced/Metastatic EGFR-mutated NSCLC

EP. 6 Considerations for Treatment of Advanced/Metastatic EGFR-mutated NSCLC

What are your treatment goals for patients with EGFR-mutated A/M NSCLC?
How do you discuss combination therapy with your high-risk EGFR-mutated locally advanced/metastatic patients?
How has your practice adapted given recent data?

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