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Opinion|Videos|June 5, 2025

Recent Advances in First-Line Combination Therapy for EGFR-mutated Metastatic NSCLC: Exploring Amivantamab + Lazertinib and Osimertinib-Based Regimens

Author(s)Rachel E. Sanborn, MD

An expert discusses recent updates on first-line treatments in EGFR-mutated NSCLC, including the MARIPOSA trial comparing amivantamab + lazertinib vs osimertinib, and the FLAURA2 trial of osimertinib + chemotherapy, and how the data is likely to impact the treatment landscape.

Episodes in this series

EP. 1 A 55-Year-Old Man with EGFR-mutated Advanced/Metastatic NSCLC

EP. 1 A 55-Year-Old Man with EGFR-mutated Advanced/Metastatic NSCLC

EP. 2 Recent Advances in First-Line Combination Therapy for EGFR-mutated Metastatic NSCLC: Exploring Amivantamab + Lazertinib and Osimertinib-Based Regimens

EP. 2 Recent Advances in First-Line Combination Therapy for EGFR-mutated Metastatic NSCLC: Exploring Amivantamab + Lazertinib and Osimertinib-Based Regimens

EP. 3 An Academic Perspective to Making First-Line Treatment Decisions for EGFR-mutated Metastatic NSCLC

EP. 3 An Academic Perspective to Making First-Line Treatment Decisions for EGFR-mutated Metastatic NSCLC

EP. 4 First-Line Treatment Approaches for EGFR-mutated Metastatic NSCLC: Updates from MARIPOSA High-Risk Analyses

EP. 4 First-Line Treatment Approaches for EGFR-mutated Metastatic NSCLC: Updates from MARIPOSA High-Risk Analyses

EP. 5 Management of Adverse Events with First-Line Combination Therapies for EGFR-mutated NSCLC

EP. 5 Management of Adverse Events with First-Line Combination Therapies for EGFR-mutated NSCLC

EP. 6 Considerations for Treatment of Advanced/Metastatic EGFR-mutated NSCLC

EP. 6 Considerations for Treatment of Advanced/Metastatic EGFR-mutated NSCLC

Please discuss recent updates on first-line (1L) treatments in EGFR-mutated NSCLC.

How do you see recent data impacting the treatment landscape?

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