Updated phase 2 data showed a 60% ORR and 86% CNS ORR with frontline silevertinib in non-classical EGFR-mutant NSCLC; FDA discussion supported a phase 3 trial in 2027.
|Videos|June 9, 2014
ARAF as a New Driver in Lung Adenocarcinoma
Author(s)Luiz H. Araujo, MD
Luiz H. Araujo, MD, medical oncologist, Corporate Cancer Foundation fellow, Ohio State’s Comprehensive Cancer Center – James Cancer Hospital and Solove Research Institute, discusses the discovery of oncogenic ARAF as a new driver for lung cancer.
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Luiz H. Araujo, MD, medical oncologist, Corporate Cancer Foundation fellow, Ohio State’s Comprehensive Cancer Center James Cancer Hospital and Solove Research Institute, discusses the discovery of oncogenicARAFas a new driver for lung cancer.
Clinical Pearls:
- When a 66-year-old lung cancer patient responded to sorafenib, her tumor and normal tissue was taken for sequencing.
- Researchers found a new mutation called ARAF.
- When ARAF is placed in cell lines, the cell lines develop tumors.
- It was found that sorafenib can reverse the phenotype.
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