Updated phase 2 data showed a 60% ORR and 86% CNS ORR with frontline silevertinib in non-classical EGFR-mutant NSCLC; FDA discussion supported a phase 3 trial in 2027.
|Videos|March 27, 2020
A 62-Year-Old Woman With Metastatic BRAF V600E-Mutated NSCLC
A 62-Year-Old Woman With Metastatic BRAF V600E-Mutated NSCLC
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Case: A 62-Year-Old Woman With MetastaticBRAFV600E-Mutated NSCLC
Initial Presentation
- A 62-year-old woman presented with a 4-month history of chronic cough, dyspnea, loss of appetite and weight loss
- PMH/SH: 25 pack-year smoking history, quit 12 years ago
- PE: Right-sided wheezing on auscultation
Clinical Workup
- Labs: WNL
- Chest/abdomen/pelvic CT showed a 2.5-cm solid pulmonary lesion in the left inferior lobe, ipsilateral peribronchial lymph node involvement and multiple small hepatic lesions
- Bronchoscopic biopsy of the lung lesion and lymph node revealed lung adenocarcinoma
- Contrast‐enhanced MRI of the head showed no evidence of metastases
- Molecular and biomarker testing: BRAFV600E+,EGFR-, ALK-, ROS1-,PD-L1 0%
- Stage T1cN1M1c; ECOG PS 0
Treatment and Follow-Up
- Started on dabrafenib 150 mg PO qDay BID + trametinib 2 mg PO qDay; achieved a partial response
- Patient developed intermitted nausea and vomiting, medically controlled
- Imaging at 3,6 and 9 months showed sustained partial response
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