Arvind Dasari, MD, MS, reviews key advances in neuroendocrine tumors, including new PRRT options, alpha emitters, cabozantinib, and clinical trials.
|Videos|April 30, 2019
A 58-Year-Old Woman with Polycythemia Vera
A 58-Year-Old Woman with Polycythemia Vera
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Case: 58-Year-Old Woman Diagnosed With Polycythemia Vera
November 2018
- A 58-year old woman presents to PCP complaining of abdominal pain, dizziness and headaches
- PE: BP 140/85; Splenomegaly ~6 cm below left costal margin
- PMH: No prior history of thrombosis
- Lab values:
- HGB: 17.1 g/dL
- Hct: .50 L/L
- RBC: 71 x 1012/L
- WBC: 13.2 x 109/L
- Serum EPO: 4.1 mU/mL
- Bone Marrow Biopsy: Erythroid hyperplasia
- Cytogenetics: JAK-V617Fmutation
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Arvind N. Dasari, MD, MS, reviews a year in neuroendocrine tumors marked by expanding radioligand options, improved classification, and disappointing combination therapies.
Older age, kidney disease, and prior irradiation were linked to elevated myeloid neoplasm risk after lutetium Lu 177 dotatate in a real-world NET analysis.
Aman Chauhan, MD, discusses combining intratumoral Seneca Valley virus (SVV-001) with ipilimumab and nivolumab in neuroendocrine cancer.
Claire K. Mulvey, MD, explains how patient-reported outcomes and QOL assessments reveal NEN symptom burden and help guide treatment.
Nikolaos Trikalinos, MD, reviews CABINET data showing cabozantinib improved PFS in functional and nonfunctional NETs without added grade 3 toxicity.
Liver transplant led to durable survival in unresectable NET liver metastases; tumor burden predicted outcomes, and recurrence was common but treatable.
Mark A. Lewis, MD, explains how oral cabozantinib reduces time toxicity for patients with previously treated, well-differentiated neuroendocrine tumors.
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