Case 1: 72-Year-Old Woman With Small Cell Lung Cancer

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EP: 1.Case 1: 72-Year-Old Woman With Small Cell Lung Cancer

EP: 2.Case 1: Extensive-Stage Small Cell Lung Cancer Background

EP: 3.Case 1: IMpower133 Trial in Small Cell Lung Cancer

EP: 4.Case 1: CASPIAN Trial in Extensive-Stage Small Cell Lung Cancer

EP: 5.Case 1: Biomarkers in Small Cell Lung Cancer

EP: 6.Case 1: Small Cell Lung Cancer in the Era of Immunotherapy

EP: 7.Case 2: 67-Year-Old Woman With EGFR+ Non–Small Cell Lung Cancer

EP: 8.Case 2: Biomarker Testing for Non–Small Cell Lung Cancer

EP: 9.Case 2: EGFR-Positive Non–Small Cell Lung Cancer

EP: 10.Case 2: FLAURA Study for EGFR+ Metastatic NSCLC

EP: 11.Case 2: EGFR+ NSCLC Combination Therapies

EP: 12.Case 2: Treatment After Progression of EGFR+ NSCLC

EP: 13.Case 3: 63-Year-Old Man With Unresectable Stage IIIA NSCLC

EP: 14.Case 3: Molecular Testing in Stage III NSCLC

EP: 15.Case 3: Chemoradiation for Stage III NSCLC

EP: 16.Case 3: PACIFIC Trial in Unresectable Stage III NSCLC

EP: 17.Case 3: Standard of Care in Unresectable Stage III NSCLC

EP: 18.Case 3: Management of Immune-Related Toxicities in Stage III NSCLC

Mark Socinski, MD: Thank you for joining us for this Targeted Oncology™ Virtual Tumor Board® focused on advanced lung cancer. In today’s presentations my colleagues and I will review three clinical cases. We will discuss an individualized approach to treatment for each patient, and we’ll review key clinical trial data that impact our decisions. I’m Dr. Mark Socinski from the AdventHealth cancer institute in Orlando, Florida. Today I’m joined by Dr Ed Kim, a medical oncologist from the Levine Cancer Institute in Charlotte, North Carolina; Dr Brendon Stiles, who is a thoracic surgeon from the Weill Cornell Medical Center in New York ; and Dr Tim Kruser, radiation oncologist from Northwestern Medicine Feinberg School of Medicine in Chicago. Thank you all for joining me today. We’re going to move to the first case, which is a case of small cell lung cancer. I’m going to ask Dr Kim to do the presentation.

Edward Kim, MD: Thanks, Mark. It’s my pleasure to walk us through the first case, which is small cell lung cancer. This is a case with a 72-year-old woman who presents with shortness of breath, a productive cough, chest pain, some fatigue, anorexia, a recent 18-pound weight loss, and a history of hypertension. She is a schoolteacher and has a 45-pack-a-year smoking history; she is currently a smoker. She is married, has 2 kids, and has a grandchild on the way. On physical exam she had some dullness to percussion with some decreased-breath sounds, and the chest x-ray shows a left hilar mass and a 5.4-cm left upper-lobe mass. CT scan reveals a hilar mass with a bilateral mediastinal extension. Negative for distant metastatic disease. PET scan shows activity in the left upper-lobe mass with supraclavicular nodal areas and liver lesions, and there are no metastases in the brain on MRI. The interventional radiographic test biopsy for liver reveals small cell, and her PS is 1. Right now we do have a patient who has extensive-stage small cell lung cancer. Unfortunately, it’s what we found. It’s very common to see this with liver metastases.

Transcript edited for clarity.