Updated phase 2 data showed a 60% ORR and 86% CNS ORR with frontline silevertinib in non-classical EGFR-mutant NSCLC; FDA discussion supported a phase 3 trial in 2027.
|Videos|October 7, 2014
Ceritinib For Lung Cancer Treatment
Author(s)Quincy Chu, MD
Quincy Chu, MD, associate professor, medical oncologist, University of Alberta, discusses the development of ceritinib.
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Quincy Chu, MD, associate professor, medical oncologist, University of Alberta, discusses the development of ceritinib.
Clinical Pearls:
- Ceritinib is a second-generation ALK inhibitor
- In a preclinical setting, ceritinib was found to have activity to the ALK-amplified cell lines as well as in human samples
- Unlike crizotinib, ceritinib does have substantial CNS penetration ​
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