Dr. Charles Perou on Molecular Differences in Lobular Breast Cancer

March 22, 2016
Charles Perou, PhD

Perou says this research also found three expression subtypes within lobular breast cancer, one of which showed a proliferative phenotype and portended a slightly worse prognosis.

Charles Perou, PhD, professor of Genetics, Pathology & Laboratory Medicine, Lineberger Comprehensive Cancer Center, UNC School of Medicine, discusses a recent paper published from The Cancer Genome Atlas focusing on lobular breast cancer as a distinct molecular disease. Perou says this research also found three expression subtypes within lobular breast cancer, one of which showed a proliferative phenotype and portended a slightly worse prognosis.

He adds that the other two subtypes of lobular breast cancer were defined by unique features of the microenvironment. In one of the two subtypes, Perou says there appeared to be immune cell infiltrates, while in the other subtype there appeared to be fibroblasts and other types of stromal cell infiltrates.