Guess the Diagnosis: Case 1 - Episode 1
Dr. David Fajgenbaum, Perelman School of Medicine, University of Pennsylvania, says that this is a 47-year-old female who presents with a 10-month history of systemic symptoms comprising night sweats, fatigue, and weight loss accompanied by laboratory values pointing to an inflammatory syndrome or malignancy. [Because] she has generalized lymphadenopathy, the differential diagnosis includes lymphoma, chronic infection, or a systemic inflammatory syndrome [such] as seen in autoimmune disorders. The negative antinuclear antibody (ANA) and other rheumatologic serologies make an autoimmune disorder unlikely. The standardized uptake value (SUV) in the lymph nodes on the positron emission tomography (PET) scan is not very high, but does not rule out lymphoma. The lymph node fine needle aspiration (FNA) was not informative, and the patient was correctly referred for excisional lymph node biopsy.
What does the patient’s initial presentation suggest to you?
Guess the Diagnosis: Case 1
Lisa B. is a 47-year-old female store owner from St. Louis, with a 10-month history of fatigue, night sweats, and weight loss.
Lisa’s pathology report shows the following findings:
In view of these findings, the hematologist orders further tests, which yield the following results: