CLL Case Review: IgHV-Unmutated Therapy Options

April 26, 2019

CLL Case Review: IgHV-Unmutated Therapy Options


Case:A 74-Year-Old Male WithIgVH-Unmutated CLL

  • A 74-year-old male presented to PCP with complaints of extreme fatigue, weakness, and weight loss of ~15lbs over the last 3 months.
  • PMH: Mild hypertension managed by statin
  • PE: BP 135/85, enlarged lymph nodes (~6cm), palpable spleen approx. 7cm below costal margin
  • Laboratory findings:
    • WBC; 100 X 109/L
    • Lymphocytes; 82 X 109/L
    • Hb; 15.1 g/dL
    • Platelets; 125 X 109/L
    • ANC; 1,800/mm3
    • LDH 250 u/L
  • β2M, 4.3 mg/L
  • FISH; normal
  • Molecular analysis;IgVH-,TP53wild-type
  • ECOG PS 1
  • Rai Stage II