|Videos|July 23, 2018

Therapeutic Approach for IDH2-Mutated AML

Case: A 65-Year-Old Woman withIDH2-Mutated AML

November 2017

A 65-year-old female was diagnosed with AML, normal cytogenetics;IDH2R140,RUNX1,andDNMT3Amutations
7+3 induction chemotherapy was initiated
Her treatment course was complicated by mucositis and febrile neutropenia
After resolution of her complications, she received 2 cycles of intermediate-dose cytarabine consolidation

May 2018

Now, 6 months after her initial diagnosis, she presents with fatigue, aches, and gum bleeding
Labs: leukocytosis, 20% circulating myeloblasts, ANC 450 cells/mL
Bone marrow biopsy: hypercellular 80% blast, normal cytogenetics
NGS: mutations inIDH2,RUNX1,andDNMT3A

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