Therapeutic Approach for IDH2-Mutated AML

July 23, 2018

Therapeutic Approach for IDH2-Mutated AML


Case: A 65-Year-Old Woman withIDH2-Mutated AML

November 2017

  • A 65-year-old female was diagnosed with AML, normal cytogenetics;IDH2R140,RUNX1,andDNMT3Amutations
  • 7+3 induction chemotherapy was initiated
  • Her treatment course was complicated by mucositis and febrile neutropenia
  • After resolution of her complications, she received 2 cycles of intermediate-dose cytarabine consolidation

May 2018

  • Now, 6 months after her initial diagnosis, she presents with fatigue, aches, and gum bleeding
  • Labs: leukocytosis, 20% circulating myeloblasts, ANC 450 cells/mL
  • Bone marrow biopsy: hypercellular 80% blast, normal cytogenetics
  • NGS: mutations inIDH2,RUNX1,andDNMT3A