Dr. Paul Walfish on PD-1 Expression in Thyroid Cancer

October 24, 2015
Paul Walfish, MD

Paul Walfish, MD, professor emeritus at the University of Toronto School of Medicine, senior consult Mount Sinai Hospital discusses programmed death ligand 1 (PD-1) expression in aggressive metastatic papillary thyroid cancer.

Paul Walfish, MD, professor emeritus at the University of Toronto School of Medicine, senior consult Mount Sinai Hospital discusses programmed death ligand 1 (PD-1) expression in aggressive metastatic papillary thyroid cancer.

To determine if PD-1 was expressed in either the cytoplasm of the cell or the membrane, Walfish and his team created a scoring system using immunohistochemistry. They determined a score of 4.7 for cytoplasm and 1.7 for the membrane was the required to show positive PD-1 expression.

They found that there was increasing expression of PD-1 as the severity of the cancer increased, with some scores up to 7.