Dutasteride for the Treatment of Prostate Cancer

May 9, 2014
Rana R. McKay, MD

Rana R. McKay, MD, a clinical oncology fellow at Dana-Farber Cancer Institute, discusses the mechanism of action of dutasteride and its role in a phase II prostate cancer trial.

Clinical Pearls

Rana R. McKay, MD, a clinical oncology fellow at Dana-Farber Cancer Institute, discusses the mechanism of action of dutasteride and its role in a phase II prostate cancer trial.

  • Dutasteride is a dual 5-α reductase inhibitor that prevents the conversion of testosterone to DHT. It is classically used for people with benign prostatic hypertrophy.
  • In a phase II trial, dutasteride was combined with abiraterone acetate for the treatment of metastatic castration resistant prostate cancer.