Later Line Therapeutic Decisions in Metastatic HCC

May 18, 2017

Later Line Therapeutic Decisions in Metastatic HCC


February 2014

  • A 63-year old male with HBV
  • ECOG=0
  • Child-Pugh A; platelet count 230,000 cells/mcL
  • Bilirubin 1.0 mg/dL; Albumin 3.5 g/dL
  • CT scan revealed liver lesions, 1 is 2-cm; 1 is 5-cm both in the right lobe
  • No extrahepatic disease
  • Biopsy confirmed HCC diagnosis
  • AFP=5400 IU/ml
  • Tumors were resected with RO margin

August 2016

  • Imaging showed recurrence in the liver, metastatic disease in the lungs
  • Therapy was initiated with sorafenib 400 mg BID
  • Therapy was well-tolerated

April 2017

  • Radiographic progression with multiple lung metastases
  • ECOG=0
  • Therapy with regorafenib initiated at 160 mg
  • Starting dose was well-tolerated, patient experienced some fatigue