Later Line Therapeutic Decisions in Metastatic HCC: Case 2

January 2017

• A 74-year old female with a history of HCV-infection
• Prior treatment with interferon, achieving sustained virologic response
• Had recurrence of HCV
• CT scan showed a 6.5-cm single liver mass with arterial enhancement, venous phase washout, and main portal vein invasion
• ECOG=1
• Child-Pugh A
• Therapy was initiated with sorafenib at 400 BID
• Patient experienced grade 3 hand-foot skin reaction; dose reduction to 400 QD
• Patient experienced grade 3 diarrhea; dose reduction to 400 QOD

April 2017

• Follow-up scans show radiographic progression with lung metastases