B-cell malignancies include non-Hodgkin lymphomas (NHL) and chronic lymphocytic leukemia (CLL). NHLs are a heterogeneous group of more than 30 cancers of B lymphocytes and T lymphocytes.
In the United States, B-cell lymphomas comprise about 85% of all NHL. Regarding these B-cell lymphomas, diffuse large B-cell lymphoma (DLBCL) has the highest incidence of 30%, followed by follicular lymphoma (20%).2More than 70, 000 new cases and almost 19,000 deaths are expected as a result of NHL in 2014.3An estimated 15,720 new cases of CLL and 4600 deaths are expected in 2014.4NHL and leukemia are the seventh and eleventh commonest neoplasms, respectively, in the US, with CLL accounting for about one third of leukemia cases.3-5
Common general risk factors for B-cell NHL and CLL are:
Differences in risk factors: