Treating AML With Myelodysplasia-Related Changes

Case: A 68-Year-Old Man With Newly-diagnosed AML

• A 68-year-old man went to the emergency room with complaints of dizziness and chest pain
  • Myocardial infarction diagnosed and managed in hospital
  • During stay, CBC revealed decreased neutrophils but increased total white blood cell count
  • When stable from MI, he was referred for specialist consultation
• Patient history and physical exam:
  • Reported fatigue, shortness of breath with minor exertion, and unexplained weight loss that have worsened over the past 2 months
  • Over the 6 months, has experienced three upper respiratory infections, often with mild fever, that were refractory to treatment, but which he attributed to being a former smoker
  • No history of cancer or cytotoxic treatment
• Laboratory findings:
  • Absolute neutrophil count: 600 cells/µL; WBC: 85,000 cells/µL
  • Peripheral blood shows poorly differentiated myeloid cells
  • 25% blasts in peripheral blood
  • Cytogenetic abnormalities: chromosome 5 (del[5q])
• Diagnosed with acute myeloid leukemia with myelodysplastic-related changes
• Received Vyxeos (CTX-351) induction therapy, followed by consolidation
  • Experienced complete response and underwent HSCT