<em>ESR1</em> Mutations in Primary Breast Cancer

Clinical Pearls

Suzanne A. W. Fuqua, PhD, professor of medicine at Baylor College of Medicine, discussesESR1mutations in primary breast cancer.

• There is some controversy surrounding whether or notESR1mutations are associated with primary breast cancer.
• It has been reported that the K303R mutation was present in premalignant breast cancer as well as in primary breast tumors.
• Further research is needed to validate the presence and frequency of the K303R mutation in primary breast cancer.