Relapse After Second-Line Therapy in Follicular Lymphoma

Video

Relapse After Second-Line Therapy in Follicular Lymphoma

Case:A 72-Year-Old Woman With Relapsed Follicular Lymphoma

H & P:

  • A 75-year-old woman presented with severe fatigue and weight loss
  • Was diagnosed with inguinal contiguous stage II follicular lymphoma (FL) 4.5 years ago; completed BR and achieved PR that persisted for almost 4 years
  • Started treatment with R-CHOP for extensive mediastinal FL 6 months ago; had achieved PR by 3 months before symptoms returned
  • PMH: Type 2 diabetes X 10 years, controlled on basal insulin and SGLT2 inhibitor
  • PE: Swelling present in right axillary lymph nodes; not tender to touch; no crackles or rales in lungs; no history of pneumonia; has received flu and PPV23 vaccination
  • ECOG performance status: 1
  • Biopsy showed grade 2 FL without transformation
  • Labs:
    • eGFR = 72 mL/min/1.732
    • AST/ALT: within normal range
    • ANL: 1350 /mm3
    • Platelets: 100,00 /µL
    • Hemoglobin: 10 g/dL
    • LDH: 275 U/L
  • Imaging: PET/CT revealed axillary lymphadenopathy, with largest mass 7.2 cm
  • She was started on idelalisib 150 mg b.i.d.
  • After 10 days, she called with concerns about diarrhea, which she has been experiencing on average 4 times daily for the past few days
Related Videos
Video 3 - "Managing Toxicities and Adverse Reactions in HR+/Her2-Low mBC Therapies"
Video 2 - "EMERALD: Underscoring Key Elacestrant Data + Subgroup Analyses for Informed Therapy Selection"
Video 1 - "A 62-Year-Old Woman with HR+ HER2-low Metastatic Breast Cancer and Lung, Liver, and Bone Metastases and Using Biomarker Testing to Guide Treatment Selection"
John Mascarenhas, MD, an expert on myelofibrosis
John Mascarenhas, MD, an expert on myelofibrosis
John Mascarenhas, MD, an expert on myelofibrosis
John Mascarenhas, MD, an expert on myelofibrosis
John Mascarenhas, MD, an expert on myelofibrosis
Related Content