Investigating Resistance in ROS1+ Lung Cancer
Robert C. Doebele, MD, PhD, discusses resistance in patients with ROS1-positive lung cancer.
Robert C. Doebele, MD, PhD, associate professor at the University of Colorado, discusses resistance in patients withROS1-positive lung cancer.
According to Doebele, studies are still early in this patient population, but 2 have been published so far. Both showed thatROS1mutations can occur, but data published from the University of Colorado, showed a rate of about 10%, while the study from Massachusetts General Hospital showed about 50%.
While these results are very different, both studies were relatively small. Doebele believes it might be around 30%, as withALK+lung cancer. Drugs need to be developed to overcome kinase domain mutations in ROS1, but first investigators must identify what those resistance mutations are and the other type of resistance mechanisms in ROS1+
KRAS G12C Inhibitors Show Promise as Second-Line Treatment of NSCLC
November 27th 2023During a Targeted Oncology™ Case-Based Roundtable™ event, Devika Das, MD, discussed the role of KRAS inhibitors and the outcome of the KRYSTAL-1 trial in patients with non–small cell lung cancer. This is the first of 2 articles based on this event.
Read More
BRUIN MCL-321 Trial Evaluates Pirtobrutinb Monotherapy in MCL
November 20th 2023In an interview with Targeted Oncology, Michael Wang, MD, discussed the rationale of the phase 3 study and how positive results from this trial may further shape the mantle cell lymphoma treatment landscape.
Read More
