How has the availability of targeted therapies influenced treatment options for patients with leiomyosarcoma?
This patient has received first-, second-, and third-line chemotherapy regimens that are standard of care for patients with advanced leiomyosarcoma. A newer agent, termed trabectedin, has been shown in a randomized study to be superior to dacarbazine in terms of progression-free survival.
In this patient, I would use as the next line of therapy trabectedin, given as 1.5 m/g2continuous infusion every 3 weeks.
CASE: Soft-Tissue Sarcoma (Part 1)
Rachel F is a 58-year-old school teacher from Roanoke, Virginia. Her medical history is notable for mild hypertension and total knee replacement in 2011
Follow-up CT scan in January 2014 showed progression at multiple sites; at the time of follow up, her ECOG performance status was 1, with renal and hepatic function within normal limits
In September of 2014 she returns for follow-up, unable to work with increasing fatigue and abdominal pain, and her CT scan was consistent with progressive disease
After 4 months of therapy, she presents with worsening abdominal pain and declining performance status
Need for Systemic Therapy Remains in Sarcoma
November 27th 2023In an interview with Targeted Oncology, Lisa B. Ercolano, MD, discussed the evolving treatment landscape for sarcomas and underscored the pivotal role of molecular profiling, while addressing the need for more efficacious systemic therapies.
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