Key Takeaways from the First-in-Human Study of Odronextamab in B-cell NHL
Rajat Bannerji, MD, PhD, discussed key takeaways from the phase 1 study of the novel CD20xCD3 bispecific antibody, odronextamab in patients with highly refractory B-cell non-Hodgkin lymphoma.
Rajat Bannerji, MD, PhD, of the Rutgers Cancer Institute of New Jersey discussed key takeaways from the phase 1 study of the novel CD20xCD3 bispecific antibody, odronextamab in patients with highly refractory B-cell non-Hodgkin lymphoma (NCT0229095).
The first-in-human phase one study is to determine the safety, tolerability, and appropriate dosage of odronextamab. The dose-escalation portion of the study is complete with results having been presented at the American Society of Hematology (ASH) Annual Meeting & Exposition 2019.
Researchers presented longer follow-up data at ASH 2020 on durable response rates and ongoing remission. According to the study, an overall response rate of 55% was achieved with all patients achieving a complete response. Of those who responded, 83% were durable responses, meaning response lasted at least 3 months. At the time of data cutoff, 1 patient had a durable response of 21 months.
Navigating ESR1 Mutations in HR-Positive Breast Cancer With Dr Wander
October 31st 2024In this episode of Targeted Talks, Seth Wander, MD, PhD, discusses the clinical importance of ESR1 mutations in HR-positive metastatic breast cancer and how these mutations influence treatment approaches.
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Isatuximab Plus VRd Enhances MRD Negativity and Responses in Transplant-Ineligible NDMM
December 10th 2024The phase 3 IMROZ trial showed isatuximab plus VRd and Rd maintenance improved MRD negativity and responses versus VRd alone in transplant-ineligible newly diagnosed multiple myeloma.
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