Elranatamab reduced the risk of disease progression or death vs standard care in patients with R/R myeloma after prior anti-CD38 therapy and lenalidomide.
|Videos|July 9, 2018
Treatment Options and Care for Patients Who Develop Therapy-Related AML
Treatment Options and Care for Patients Who Develop Therapy-Related AML
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Case: A 67-Year-Old Man with Therapy-Related AML
- A 67-year-old man who had received CHOP for diffuse large B-cell lymphoma 3 years prior
- PMH: hypertension controlled with amlodipine
- Laboratory results:
- WBC 15 x 109/L
- Serum creatinine 1.5 mg/dL
- Normal LFTs
- LVEF 50%
- Diagnosis: Acute Myeloid Leukemia
- ECOG PS 1
- The patient received liposomal cytarabine and daunorubicin
- His course was complicated by febrile neutropenia
- After induction, <5% marrow blasts, neutrophil count (>1400/µL), platelets 60,000/µL
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The investigational menin inhibitor is being evaluated in a registrational phase 2 trial for patients with relapsed or refractory acute leukemia.
The phase 3 VERIFY trial found that rusfertide improved clinical response, reduced phlebotomy requirements, and eased symptom burden in patients with polycythemia vera receiving standard-of-care therapy.
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