|Videos|April 29, 2019

JAK Inhibition for the Management of Primary Myelofibrosis

Case: 66-Year-Old Man Diagnosed With Primary Myelofibrosis

January 2019

A 66-year old man presents to primary care physician with complaints of fatigue, headache, and abdominal discomfort when taking deep breaths
PMH: depression
PE: Splenomegaly ~7 cm below left costal margin
Lab values:
- HGB: 9.2 g/dL
- Platelets: 242 x 10⁹/L
- WBC: 26.2 x 10⁹/L
- Serum LDH: 1400 U/L
- Serum EPO: 10.9 mU/mL
Bone Marrow Biopsy:
- MF-3
- Circulating blasts, 1.1%
- JAK V617Fmutation; trisomy 8
Peripheral Blood Smear: leukoerythroblastosis
Diagnosis: Primary myelofibrosis

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JAK Inhibition for the Management of Primary Myelofibrosis

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