Commentary|Articles|October 31, 2026

Lonardi on Overall Survival With Nivolumab/Ipilimumab in MSI-H/dMMR mCRC

Sara Lonardi, MD, discusses the final overall survival analysis of CheckMate-8HW from ESMO 2026 and its implications for first-line MSI-H/dMMR mCRC.

At the 2026 European Society for Medical Oncology (ESMO) Congress, Sara Lonardi, MD, presented the final overall survival (OS) analysis of the phase 3 CheckMate-8HW trial (NCT04008030), which evaluated nivolumab (Opdivo) plus ipilimumab (Yervoy) vs nivolumab monotherapy or chemotherapy in patients with microsatellite instability–high (MSI-H) or mismatch repair–deficient (dMMR) metastatic colorectal cancer (mCRC).1,2

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