Opinion|Videos|December 17, 2025

Long-Term Data From SEQUOIA Study of Zanubrutinib in CLL

Author(s)Marc S. Hoffmann, MD

Dr. Marc S. Hoffmann reveals promising 6-year results from the SEQUOIA study on zanubrutinib for chronic lymphocytic leukemia at the 2025 ASH Meeting.

Episodes in this series

1 panelist

EP. 1 Long-Term Data From SEQUOIA Study of Zanubrutinib in CLL

1 panelist

EP. 2 3-Year Data From SEQUOIA Arm D: Zanubrutinib Plus Venetoclax in Treatment-Naive, High-Risk CLL

1 panelist

EP. 3 Long-Term Follow-Up Data From ALPINE: Zanubrutinib Vs Ibrutinib in R/R CLL.

1 panelist

EP. 4 Sonrotoclax in R/R Mantle Cell Lymphoma After BTKi

Marc S. Hoffmann, MD, discusses 6-year data from the phase 3 SEQUOIA study, which evaluated the BTK inhibitor zanubrutinib in patients with treatment-naive chronic lymphocytic leukemia. The results were presented at the 2025 ASH Annual Meeting. Hoffman shares long-term progression free survival outcomes for 2 of the study arms: Arm A, in which patients without del(17p) received zanubrutinib monotherapy and were compared to a group of patients who received bendamustine and rituximab; and the nonrandomized Arm C, in whichpatients with del(17p) received zanubrutinib monotherapy.

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