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Opinion|Videos|December 24, 2025

3-Year Data From SEQUOIA Arm D: Zanubrutinib Plus Venetoclax in Treatment-Naive, High-Risk CLL

Author(s)Marc S. Hoffmann, MD

A recent study reveals promising results for CLL patients using zanubrutinib and venetoclax, highlighting effective time-limited therapy options.

Episodes in this series

1 panelist

EP. 1 Long-Term Data From SEQUOIA Study of Zanubrutinib in CLL

1 panelist

EP. 2 3-Year Data From SEQUOIA Arm D: Zanubrutinib Plus Venetoclax in Treatment-Naive, High-Risk CLL

1 panelist

EP. 3 Long-Term Follow-Up Data From ALPINE: Zanubrutinib Vs Ibrutinib in R/R CLL.

1 panelist

EP. 4 Sonrotoclax in R/R Mantle Cell Lymphoma After BTKi

Marc S. Hoffmann, MD, highlights 3-year results from SEQUOIA trial arm D, a nonrandomized cohort that examined a fixed-duration combination of the BTK inhibitor zanubrutinib plus the BLC2 inhibitor venetoclax in patients with treatment-naive CLL with del(17p) and/or TP53 mutation, but not both. Hoffmann describes efficacy outcomes and discusses continuous and fixed-duration therapy options in this setting.

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