Opinion|Videos|December 31, 2025

Long-Term Follow-Up Data From ALPINE: Zanubrutinib Vs Ibrutinib in R/R CLL.

Author(s)Marc S. Hoffmann, MD

A recent study reveals promising results for CLL patients using zanubrutinib and venetoclax, highlighting effective time-limited therapy options.

Episodes in this series

1 panelist

EP. 1 Long-Term Data From SEQUOIA Study of Zanubrutinib in CLL

1 panelist

EP. 2 3-Year Data From SEQUOIA Arm D: Zanubrutinib Plus Venetoclax in Treatment-Naive, High-Risk CLL

1 panelist

EP. 3 Long-Term Follow-Up Data From ALPINE: Zanubrutinib Vs Ibrutinib in R/R CLL.

1 panelist

EP. 4 Sonrotoclax in R/R Mantle Cell Lymphoma After BTKi

The phase 3 ALPINE trial compared the BTK inhibitors zanubrutinib and ibrutinib in patients with relapsed/refractory (R/R) chronic lymphocytic leukemia. In this video, Marc S. Hoffmann, MD, discusses 6-year data from the trial that were presented at the 2025 ASH Annual Meeting. Hoffman highlights efficacy results and discusses optimizing treatment approaches for patients in the R/R setting.

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