Sequential Therapy for Metastatic Pancreatic Cancer

April 10, 2017

Sequential Therapy for Metastatic Pancreatic Cancer


April 2015

  • A 66-year—old female presented to her gastroenterologist with jaundice, weight loss, upper right quadrant abdominal pain, and diarrhea. She continued to carry out normal activity but reported requiring rest on most days.
  • CA19-9: 2296 U/ml
  • Abdominal CT scan showed an expansive lesion measuring 39 × 26 mm between the pancreas and inferior vena cava, below the portal vein. There was enlarged para-aortic lymph node and stenosis of the common bile duct.
  • Endoscopic retrograde cholangiopancreatography was performed and the patient was referred for surgery.
  • Explorative laparotomy showed the mass to be inoperable because of local vascular infiltration and liver metastases.
  • Pathophysiology confirmed pancreatic adenocarcinoma; stage T4N1M1

May 2015

  • The patient was started on gemcitabine + albumin-bound (nab) paclitaxel
  • She complained of moderate nausea and fatigue for the first 4 weeks of therapy which was managed with antiemetic therapy
  • Neutropenia was managed

August 2015

  • CT scan shows stable disease
  • CT scan showed no residual liver metastases; the tumor in the head of the pancreas was unchanged in size.
  • The patient is asymptomatic and continues to tolerate therapy

June 2016

  • Patient hospitalized for high blood glucose levels, diagnoses with new onset insulin-dependent diabetes mellitus
  • CT scan showed appearance of several new liver metastases
  • The patient was started on the FOLFIRINOX regimen