|Videos|September 22, 2016

Metastatic Lung Cancer with Jared M. Weiss, MD: Case 1

Metastatic Lung Cancer with Jared M. Weiss, MD

Weiss case 1:

A 65-year-old man with stage IV NSCLC.

Tissue biopsy showed EGFR+ adenocarcinoma
The patient was enrolled in a clinical trial of erlotinib vs erlotinib/bevacizumab
He was treated with erlotinib for 10 months before developing asymptomatic progression, with slowly growing lesions.
He was continued on erlotinib for 3 more months; His next scan showed rapid progression.
Repeat bronchoscopy and mutation testing showed an acquired EGFR T790M mutation
Patient was subsequently switched to osimertinib

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