|Videos|April 7, 2022

Ruxolitinib Adverse Event Data and Strategies for Managing Side Effects

Author(s)Pashna Munshi, MD

Pashna Munshi, MD, provides an overview of adverse event data from the REACH3 trial of ruxolitinib in patients with steroid-refractory cGVHD and discusses management of patients’ side effects in clinical practice.

Episodes in this series

$EP. 1 Introduction: A 58-Year-Old Man With Moderate Steroid-Refractory cGVHD and Risk Factors for cGVHD$

EP. 1 Introduction: A 58-Year-Old Man With Moderate Steroid-Refractory cGVHD and Risk Factors for cGVHD

EP. 2 Overview of cGVHD Symptoms, Diagnosis, and Tools for Severity Assessment

EP. 2 Overview of cGVHD Symptoms, Diagnosis, and Tools for Severity Assessment

$EP. 3 Steroid-Refractory cGVHD: Risk Factors and Clinical Challenges$

EP. 3 Steroid-Refractory cGVHD: Risk Factors and Clinical Challenges

$EP. 4 Treatment Options for Steroid-Refractory cGVHD$

EP. 4 Treatment Options for Steroid-Refractory cGVHD

$EP. 5 Ruxolitinib in Steroid-Refractory cGVHD and REACH3 Efficacy Data$

EP. 5 Ruxolitinib in Steroid-Refractory cGVHD and REACH3 Efficacy Data

$EP. 6 Real-World Efficacy Data for Ruxolitinib in Steroid-Refractory cGVHD$

EP. 6 Real-World Efficacy Data for Ruxolitinib in Steroid-Refractory cGVHD

EP. 7 Ruxolitinib Adverse Event Data and Strategies for Managing Side Effects

EP. 7 Ruxolitinib Adverse Event Data and Strategies for Managing Side Effects

EP. 8 Case Commentary and Considerations for Treatment and Management

EP. 8 Case Commentary and Considerations for Treatment and Management

EP. 9 Future Directions in GVHD

EP. 9 Future Directions in GVHD

Case: A 58-Year-Old Man With Moderate Steroid-Refractory Chronic Graft-Versus-Host Disease

Initial Presentation

A 58-year-old man previously underwent myeloablative conditioning and an allogeneic PBSC transplant for acute lymphocytic leukemia
Received tacrolimus and methotrexate for GVHD prophylaxis
At 10 months post-transplant, patient developed moderate muscle and joint pain with decreased range of motion, mild erythematous rash on cheeks

First-line Treatment

Patient received topical steroid cream for rash, and was started on oral prednisone at 1 mg/kg/day
After 4 weeks of treatment, the patient’s rash resolved but muscle/joint pain continued

Second-line Treatment

Patient is now receiving ruxolitinib 10 mg orally twice daily, alongside 1 mg/kg/day steroids

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