Stopping a TKI Before Chemotherapy

Clinical Pearls

Paul A. Bunn, Jr., MD, professor of medicine in medical oncology, head of the division of medical oncology, University of Colorado, discusses stopping treatment with a TKI before starting chemotherapy.

• Patients can have a flare reaction when they stop receiving a TKI.
• It was thought that continuing a TKI until the administration of chemotherapy could negate the flare reaction.
• Bunn says an oncologist could stop the TKI before starting chemotherapy.