Updated phase 2 data showed a 60% ORR and 86% CNS ORR with frontline silevertinib in non-classical EGFR-mutant NSCLC; FDA discussion supported a phase 3 trial in 2027.
|Videos|November 3, 2014
Stopping a TKI Before Chemotherapy
Paul A. Bunn, Jr., MD, professor of medicine in medical oncology, head of the division of medical oncology, University of Colorado, discusses stopping treatment with a TKI before starting chemotherapy.
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Clinical Pearls
Paul A. Bunn, Jr., MD, professor of medicine in medical oncology, head of the division of medical oncology, University of Colorado, discusses stopping treatment with a TKI before starting chemotherapy.
- Patients can have a flare reaction when they stop receiving a TKI.
- It was thought that continuing a TKI until the administration of chemotherapy could negate the flare reaction.
- Bunn says an oncologist could stop the TKI before starting chemotherapy.
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