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|Videos|June 16, 2014
The Monoclonal Antibody PF-03446962 for HCC
Author(s)Melanie B. Thomas, MD
Melanie B. Thomas, MD, discusses the potential utility for the monoclonal antibody PF-03446962 in hepatocellular carcinoma (HCC).
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Clinical Pearls
Melanie B. Thomas, MD, medical oncologist, associate director for clinical trials, Hollings Cancer Center, Medical University of South Carolina, discusses the potential utility for the monoclonal antibody
- PF-03446962 is a fully human IgG2 monoclonal antibody against ALK-1.
- Higher tumor c-MET and serum BMP-9, and low serum TGF-β and VEGFR3 were observed in patients with disease control at 12 weeks compared with patients with progressive disease.
- This agent was mostly well tolerated rashes were observed in some patients.
- PF-03446962 will be looked at next compared with placebo in the second-line for HCC.
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