The STRIDE Study: Concurrent vs Sequential Enzalutamide With Sipuleucel-T for mCRPC

Clinical Pearls

Daniel P. Petrylak, MD, Professor of Medicine (Medical Oncology) and of Urology, Professor and Co-Director, Signal Transduction Research Program, Yale Cancer Center, discusses the results of thephase II STRIDE studyin metastatic castration-resistant prostate cancer (mCRPC).

• The STRIDE study evaluated concurrent versus sequential enzalutamide in combination with sipuleucel-T for mCRPC.
• There was no difference seen in immune parameters when comparing early and delayed enzalutamide. The prime-boost effect was similar in the two arms.
• Anecdotally, no additive or synergistic toxicities were observed. Full toxicity data will be reported later.