The Week of May 27 in Review
The week of May 27 in review, featuring stories and videos on an FDA approval, T-DM1 for breast cancer, novel agents in early development, and the Notch pathway in gliomas.
Mechanisms of Resistance in Breast Cancer
FDA Approves Both Dabrafenib and Trametinib for Advanced Melanoma
Trials Examine Use of T-DM1 as Combination Therapy for HER2 Breast Cancer
Arsenic Trioxide in Acute Promyelocytic Leukemia
Spotlight on Novel Agents in Early Development
Early Treatment With T-DM1
Notch Holds Promise, but Presents Obstacles as Cancer Target
TweetGeorge W. Sledge, Jr, MD, Chief, Division of Oncology, Professor of Medicine, Stanford University School of Medicine, discusses the mechanisms of resistance in breast cancer.The FDA approved both dabrafenib (Tafinlar) and trametinib (Mekinist) for the treatment of patients with metastatic or unresectable melanoma. The FDA also approved a companion diagnostic to properly identify the patients exhibiting the mutations that are targeted by these agents.Ado-trastuzumab emtansine (Kadcyla, or T-DM1 in clinical trials) received FDA approval in February, and a number of ongoing trials now seek to determine whether the antibody-drug conjugate (ADC) can be combined with other agents.Francesco Lo-Coco, MD, Hematology, University Tor Vergata, speaks at the 2012 American Society of Hematology annual meeting about the use of arsenic trioxide in acute promyelocytic leukemia.The American Association for Cancer Research (AACR) is an annual showcase of the latest scientific cancer research, with updates on phase I, often first-in-human clinical trials. This year’s meeting theme, “Personalizing Cancer Care Through Discovery Science,” featured many presentations of novel mechanisms of action for targeting cancer. Following is a review of several studies that delved into how specific therapies work against cancer.Mark D. Pegram, MD, a professor of medicine at Stanford University Medical Center and the director of the Breast Cancer Program at the Stanford Cancer Institute, describes research into the antibody-drug conjugate T-DM1 (trastuzumab emtansine), following its FDA approval in February as a treatment for HER2-positive metastatic breast cancer.
CONVERT Trial Shows No Advantage to Once-Daily Radiotherapy for LS-SCLC
April 19th 2024The phase 3 CONVERT study suggests that twice-daily radiotherapy remains the standard for limited-stage small cell lung cancer due to its effectiveness and lower associated toxicity compared to the once-daily approach.
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Peers Discuss Role of Pola-R-CHP vs R-CHOP in Newly Diagnosed DLBCL
April 19th 2024During a Case-Based Roundtable® event, Haifaa Abdulhaq, MD discussed with participants whether the POLARIX trial influences their choice to use the pola-R-CHP as opposed to R-CHOP regimen for patients with newly diagnosed diffuse large B-cell lymphoma.
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