Aman Chauhan, MD, discusses combining intratumoral Seneca Valley virus (SVV-001) with ipilimumab and nivolumab in neuroendocrine cancer.
|Videos|September 24, 2018
HER2+ Early-Stage Breast Cancer: Perioperative Approaches
HER2+ Early-Stage Breast Cancer: Perioperative Approaches
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A 56-Year-Old Woman Receiving Adjuvant Therapy forHER2+ Breast Cancer
- A 56-year-old postmenopausal woman was referred for evaluation of a left-sided spiculated mass (2.4-cm) with scattered microcalcifications, found incidentally on screening mammography. Mammogram 12 months earlier was normal.
- Ultrasound confirmed a hypoechoic mass of approximately 2.4 cm X 2,3 cm by 1.8 cm at the 2 o’clock position in the left breast, 4 cm from the nipple. Axillary ultrasound demonstrated 3 enlarged lymph nodes with cortex thickening.
- Core biopsy of the breast mass revealed poorly differentiated invasive ductal carcinoma, ER/PR-negative, HER2 IHC 3+; lymph node sampling revealed the presence of breast cancer.
- Staging: T2N1M0
- She received neoadjuvant docetaxel and carboplatin with concurrent trastuzumab and pertuzumab.
- Surgical resection scattered microscopic foci of residual disease spanning 4 mm; no involved lymph nodes
- Re-staging, ypT1aypN0M0
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Amr Mohamed, MD, reviews zocilurtatug pelitecan phase 1/2 data in platinum-refractory extrapulmonary neuroendocrine carcinoma.
In a phase 1 trial, a single intratumoral injection of oncolytic virus SVV-001 with ipilimumab and nivolumab was safe in high-grade neuroendocrine cancers.
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