Bassel El-Rayes, MD

Patient Case With HER2+ Gastric Carcinoma

Molecular Testing for Gastric Carcinoma

Treatment Options for Gastric Carcinoma

The DESTINY-Gastric01 Trial and Mechanisms of Resistance in Gastric Carcinoma

Future Directions and Unmet Needs for Gastric Carcinoma

Case: A 66-Year Old Male With HER2+ Gastric Cancer

A 66-year-old man complains of a 4-month history of decreased appetite and diffuse abdominal pain

PMH: DM, medically controlled; colonoscopy at age 55 was unremarkable; no personal or family history of cancer

PE: bloating; abdominal pain on deep palpation; otherwise unremarkable


Labs: Hb 9.5 g/dL, plt 104 x 109/L; other lab values WNL

Endoscopy with biopsy: showed well differentiated papillary adenocarcinoma with invasion into the lamina propria

EUS: irregular borders on extraluminal surfaces with hyperechogenic spots

Abdominal/pelvic CT confirmed a 5.1 cm lesion with indistinct margins in the antrum of the stomach

Imaging showed 3 new small pulmonary lesions

Treatment changed to docetaxel + ramucirumab

Treatment was well tolerated for 4 cycles when he developed neutropenia

Patient was started on trastuzumab deruxtecan; repeat HER2 expression score was not indicated

Videos

Bassel El-Rayes, MD, reviews the case of a 66-year old man with gastric carcinoma and discusses the disease from diagnosis to unmet needs.

A 66-Year-Old Man With Gastric Carcinoma

Bassel El-Rayes, MD, chief clinical research scientist, Winship Cancer Institute of Emory University, discusses the key points physicians should consider when treating a patient with metastatic colorectal cancer (mCRC).

The first thing is the importance of multidisciplinary care, says El-Rayes. Patients with mCRC need to be discussed in a tumor board and multiple specialties should be included in the discussion in order to form the best treatment plan. Physicians should be aware of all the advantages to different therapies available, such as surgery, radiofrequency ablation, microwave ablation, radiation, and transcatheter therapies.

Bassel El-Rayes, MD, discusses the key points physicians should consider when treating a patient with metastatic colorectal cancer.

Bassel El-Rayes, MD | Authors

Articles

A 66-Year-Old Man With Gastric Carcinoma

Analyzing Necessary Steps for Treating Patients with mCRC